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Phthalic anhydride esterified chicha gum: characterization and antibacterial activity

2020Journal article Restricted access
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dc.contributor.authorSilva, Solranny Carla Cavalcante Costa
dc.contributor.authorBraz, Elton Marks Araujo
dc.contributor.authorBrito, Carla Adriana Rodrigues Sousa
dc.contributor.authorAlves, Michel Muálem Moraes
dc.contributor.authorCarvalho, Fernando Aécio Amorim
dc.contributor.authorBarreto, Humberto Medeiros
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorSilva, Durcilene Alves
dc.contributor.authorSilva-Filho, Edson C.
dc.date.accessioned2020-12-10T12:54:32Z
dc.date.available2020-12-10T12:54:32Z
dc.date.issued2020
dc.description.abstractThe objective of this research was to modify chicha gum with phthalic anhydride to obtain a new biologically active material. The chemical modification of the gum structure was proven through FTIR, elemental analysis, XRD, TG, and DSC. The derived materials demonstrated excellent inhibitory effect against P. aeruginosa and K. pneumoniae species (rating 100% inhibition) and could also inhibit Escherichia coli growth. The best antimicrobial activity observed for the derivatives suggests that chicha gum hydrophobization due to the addition of phthalic groups improved the interaction of these derivatives with bacterial cell wall components. On the other hand, the derivatives increased CC50 in macrophages but did not present acute toxicity or hemolytic activity, indicating that they are promising for use in prophylaxis or treatment of infections caused by Gram-negative bacteria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, S.C.C.C., Braz, E.M.A., Brito, C.A.R.S., Alves, M.M.M., Carvalho, F.A.A., Barreto, H.M., Oliveira, A.L., Silva, S.A., Silva-Filho, E.C. (2020). Phthalic anhydride esterified chicha gum: characterization and antibacterial activity. Carbohydrate Polymers, 251pt_PT
dc.identifier.doi10.1016/j.carbpol.2020.117077pt_PT
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10400.14/31446
dc.identifier.wosWOS:000582801500075
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation306176/2019-0pt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relation307460/2016-9pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectChemical modificationpt_PT
dc.subjectGram-negativept_PT
dc.subjectSterculia striata gumpt_PT
dc.titlePhthalic anhydride esterified chicha gum: characterization and antibacterial activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume251pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreto
person.familyNameOliveira
person.givenNameHumberto Medeiros
person.givenNameAna
person.identifier1415634
person.identifier.ciencia-id4713-31C8-A356
person.identifier.orcid0000-0001-5054-7555
person.identifier.orcid0000-0001-8012-4203
person.identifier.ridE-5699-2013
person.identifier.ridJ-3404-2013
person.identifier.scopus-author-id11940152400
person.identifier.scopus-author-id55937245800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationbc42fa97-aa34-428f-b73f-d4327706efec
relation.isAuthorOfPublication.latestForDiscoverybc42fa97-aa34-428f-b73f-d4327706efec
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relation.isProjectOfPublication.latestForDiscovery1f76a7db-2520-482f-b56b-7e01ea36dd1f

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