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Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure

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dc.contributor.authorTeixeira, Ana Margarida
dc.contributor.authorGarrido, Patrícia
dc.contributor.authorSantos, Paulo
dc.contributor.authorAlves, Rui
dc.contributor.authorParada, Belmiro
dc.contributor.authorCosta, Elísio
dc.contributor.authorAlmeida, Anabela
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorSereno, José
dc.contributor.authorPinto, Rui
dc.contributor.authorBelo, Luís
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorReis, Flávio
dc.date.accessioned2011-06-14T08:12:31Z
dc.date.available2011-06-14T08:12:31Z
dc.date.issued2010
dc.description.abstractChronic kidney disease (CKD) patients develop anemia because of the low kidney erythropoietin (EPO) production, thus promoting cardiovascular complications. The degree of renal insufficiency might determine the moment to start recombinant human erythropoietin (rhEPO) therapy, but the molecular basis for these options deserves better elucidation. This study aimed to clarify the cardio-renal effects of earlier rhEPO ther- 20 apy in rats with moderate chronic renal failure (CRF). Four groups of rats were evaluated for 15 weeks (control; rhEPO - 50 Ill/kg/week; CRF - 3/4 nephrectomy; CRF + rhEPO) to assess renal and hematology data, EPO levels, blood pressure, heart rate, peripheral catecholamines contents, serum-transforming growth factor-31 (TGF-f11), kidney gene expression of EPO, Caspase 9 (Casp9), and vascular endothelial growth factor (Vegf). This model of moderate CRF showed moderate and corrected anemia, hypertension, tachycardia, sympa- 25 thetic overactivity, and increased serum TGF-31 content. The remnant kidney showed a proliferative profile, with hypertrophy, downregulated gene expression of EPO, and upregulated gene expression of Vegf and Casp9. rhEPO treatment promoted erythrocytosis and prevented tachycardia and catecholamines increment, with a rise of serum TGF-$1. Furthermore, the decreased kidney gene expression of EPO and the overexpression of Casp9 were prevented, demonstrating a renoprotective action on the remnant kidney. In conclusion, 30 rhEPO therapy promotes a protective effect on the cardio-renal axis, which might be mainly attributed to its pro-proliferative and anti-apoptotic properties. These findings might recommend its use in earlier stages of CRF, acting as an erythropoiesis stimulating agent, to efficiently correct not only the anemia, one of the major complications in these patients, but also the succeeding adverse cardio-renal effects.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationTEIXEIRA, Ana Margarida ... [et al.] - Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure. Renal Failure. ISSN 0886-022X .Vol. 32, n.º 9 (2010), p. 1073-1080por
dc.identifier.doi10.3109/0886022X.2010.509897
dc.identifier.eissn1525-6049
dc.identifier.issn0886-022X
dc.identifier.urihttp://hdl.handle.net/10400.14/4437
dc.identifier.wosWOS:000283121700009
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInforma Healthcarepor
dc.subjectModerate chronic renal failurepor
dc.subjectrhEPO treatmentpor
dc.subjectCardio-renal protectionpor
dc.subjectProliferationpor
dc.subjectHypertrophpor
dc.subjectApoptosispor
dc.titleRecombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failurepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1080
oaire.citation.issue9
oaire.citation.startPage1073
oaire.citation.titleRenal Failure
oaire.citation.volume32
person.familyNameGarrido
person.familyNameRodrigues Santos
person.familyNameAlves
person.familyNameParada
person.familyNameCosta
person.familyNameAlmeida
person.familyNameTeixeira-Lemos
person.familyNameSereno
person.familyNamePinto
person.familyNameBelo
person.familyNameSantos-Silva
person.familyNameTeixeira
person.familyNameReis
person.givenNamePatrícia
person.givenNamePaulo
person.givenNameRui
person.givenNameBelmiro
person.givenNameElisio
person.givenNameAnabela
person.givenNameEdite
person.givenNameJosé
person.givenNameRui Manuel
person.givenNameLuís
person.givenNameAlice
person.givenNameFrederico
person.givenNameFlávio
person.identifier55546
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person.identifier.orcid0000-0002-0457-6790
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person.identifier.orcid0000-0002-3941-6850
person.identifier.orcid0000-0002-2565-3169
person.identifier.orcid0000-0002-2601-0923
person.identifier.orcid0000-0003-3401-9554
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person.identifier.scopus-author-id35102071200
person.identifier.scopus-author-id37021720200
person.identifier.scopus-author-id56219007200
person.identifier.scopus-author-id56024083800
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person.identifier.scopus-author-id7004405551
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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