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Acetylated cashew gum and fucan for incorporation of lycopene rich extract from red guava (Psidium guajava L.) in nanostructured systems: antioxidant and antitumor capacity

2021-11-30Journal article Open access
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dc.contributor.authorAndrades, Eryka Oliveira de
dc.contributor.authorCosta, João Marcos Antônio Rodrigues da
dc.contributor.authorNeto, Francisco Edmar Moreira de Lima
dc.contributor.authorAraujo, Alyne Rodrigues de
dc.contributor.authorRibeiro, Fabio de Oliveira Silva
dc.contributor.authorVasconcelos, Andreanne Gomes
dc.contributor.authorOliveira, Antônia Carla de Jesus
dc.contributor.authorSobrinho, José Lamartine Soares
dc.contributor.authorAlmeida, Miguel Peixoto de
dc.contributor.authorCarvalho, Ana P.
dc.contributor.authorDias, Jhones Nascimento
dc.contributor.authorSilva, Ingrid Gracielle Martins
dc.contributor.authorAlbuquerque, Patrícia
dc.contributor.authorPereira, Ildinete Silva
dc.contributor.authorRabello, Doralina do Amaral
dc.contributor.authorAmorim, Adriany das Graças Nascimento
dc.contributor.authorLeite, José Roberto de Souza de Almeida
dc.contributor.authorSilva, Durcilene Alves da
dc.date.accessioned2021-10-20T11:20:32Z
dc.date.available2022-10-02T00:30:24Z
dc.date.issued2021-11-30
dc.description.abstractIndustrial application of lycopene is limited due to its chemical instability and low bioavailability. This study proposes the development of fucan-coated acetylated cashew gum nanoparticles (NFGa) and acetylated cashew gum nanoparticles (NGa) for incorporation of the lycopene-rich extract from red guava (LEG). Size, polydispersity, zeta potential, nanoparticles concentration, encapsulation efficiency, transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used to characterize nanoparticles. The antioxidant activity was determinated and cell viability was evaluated in the human breast cancer cells (MCF-7) and human keratinocytes (HaCaT) by MTT assay. The toxic effect was evaluated by hemolysis test and by Galleria mellonella model. NFGa showed higher stability than NGa, having a size of 162.10 ± 3.21 nm, polydispersity of 0.348 ± 0.019, zeta potential -30.70 ± 0.53 mV, concentration of 6.4 × 109 nanoparticles/mL and 60% LEG encapsulation. Microscopic analysis revealed a spherical and smooth shape of NFGa. NFGa showed antioxidant capacity by ABTS method and ORAC assay. The NFGa presented significant cytotoxicity against MCF-7 from the lowest concentration tested (6.25-200 μg/mL) and did not affect the cell viability of the HaCaT. NFGa showed non-toxic effect in the in vitro and in vivo models. Therefore, NFGa may have a promising application in LEG stabilization for antioxidant and antitumor purposes.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.ijbiomac.2021.09.116pt_PT
dc.identifier.eid85116133977
dc.identifier.issn0141-8130
dc.identifier.pmid34563578
dc.identifier.urihttp://hdl.handle.net/10400.14/35630
dc.identifier.wos000710232400003
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntitumorpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectLycopenept_PT
dc.subjectNanoparticlespt_PT
dc.subjectPolysaccharidespt_PT
dc.titleAcetylated cashew gum and fucan for incorporation of lycopene rich extract from red guava (Psidium guajava L.) in nanostructured systems: antioxidant and antitumor capacitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1037pt_PT
oaire.citation.startPage1026pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume191pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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