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Browsing by Issue Date, starting with "2021-11-30"

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  • Acetylated cashew gum and fucan for incorporation of lycopene rich extract from red guava (Psidium guajava L.) in nanostructured systems: antioxidant and antitumor capacity
    Publication . Andrades, Eryka Oliveira de; Costa, João Marcos Antônio Rodrigues da; Neto, Francisco Edmar Moreira de Lima; Araujo, Alyne Rodrigues de; Ribeiro, Fabio de Oliveira Silva; Vasconcelos, Andreanne Gomes; Oliveira, Antônia Carla de Jesus; Sobrinho, José Lamartine Soares; Almeida, Miguel Peixoto de; Carvalho, Ana P.; Dias, Jhones Nascimento; Silva, Ingrid Gracielle Martins; Albuquerque, Patrícia; Pereira, Ildinete Silva; Rabello, Doralina do Amaral; Amorim, Adriany das Graças Nascimento; Leite, José Roberto de Souza de Almeida; Silva, Durcilene Alves da
    Industrial application of lycopene is limited due to its chemical instability and low bioavailability. This study proposes the development of fucan-coated acetylated cashew gum nanoparticles (NFGa) and acetylated cashew gum nanoparticles (NGa) for incorporation of the lycopene-rich extract from red guava (LEG). Size, polydispersity, zeta potential, nanoparticles concentration, encapsulation efficiency, transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used to characterize nanoparticles. The antioxidant activity was determinated and cell viability was evaluated in the human breast cancer cells (MCF-7) and human keratinocytes (HaCaT) by MTT assay. The toxic effect was evaluated by hemolysis test and by Galleria mellonella model. NFGa showed higher stability than NGa, having a size of 162.10 ± 3.21 nm, polydispersity of 0.348 ± 0.019, zeta potential -30.70 ± 0.53 mV, concentration of 6.4 × 109 nanoparticles/mL and 60% LEG encapsulation. Microscopic analysis revealed a spherical and smooth shape of NFGa. NFGa showed antioxidant capacity by ABTS method and ORAC assay. The NFGa presented significant cytotoxicity against MCF-7 from the lowest concentration tested (6.25-200 μg/mL) and did not affect the cell viability of the HaCaT. NFGa showed non-toxic effect in the in vitro and in vivo models. Therefore, NFGa may have a promising application in LEG stabilization for antioxidant and antitumor purposes.
    2021-11-30Journal article Open access Show more
  • Moving image and the museum: speculative spaces in 3 acts
    Publication . Santos, Luísa
    For the closing of Issue 4 of The Garage Journal, the author adopts one core methodology common to the practices of both film and curating: storytelling. All stories have a time, a space, and characters. Following the Rashomon effect, each one of the stories below could offer entirely different points on the relationships between the moving image and the museum. Similar to how a soundtrack can set a specific mood in film to heighten the emotional impact of the sights and sounds of a story, place and space can also serve to enhance the impact of characters (artworks) depicted in exhibitions, while characters can help to heighten the effect of events described in writing.
    2021-11-30Journal article Open access Show more