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CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia

2025-11-25Research article Open access
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dc.contributor.authorMiller, Thomas D.
dc.contributor.authorHickling, Alice L.
dc.contributor.authorWu, Yan I.
dc.contributor.authorZhou, Joseph H.
dc.contributor.authorHandel, Adam E.
dc.contributor.authorCoutinho, Ester
dc.contributor.authorPollak, Thomas A.
dc.contributor.authorZandi, Michael S.
dc.contributor.authorMaguire, Eleanor A.
dc.contributor.authorRosenthal, Clive R.
dc.date.accessioned2025-12-02T15:16:36Z
dc.date.available2025-12-02T15:16:36Z
dc.date.issued2025-11-25
dc.description.abstractThe hippocampus reconstructs past experiences by integrating sensory, perceptual, and conceptual information across a cortico-hippocampal autobiographical memory network. Here, in 18 human participants with amnesia, we decode the effects of bilateral focal hippocampal damage on distinct autobiographical representations using representational dissimilarity matrices (RDMs). Hippocampal pathology results in impaired generalized episodic memory retrieval RDM model fit in the left angular gyrus and in reduced distinct episodic memory RDM model fit in the right inferior frontal gyrus (rIFG), while right angular gyrus (rANG) and right orbitofrontal cortex (rOFC) fall below multiple correction thresholds. Trial-by-trial voxelrepresentational stability is reduced in the rANG, rIFG, and rOFC. The RDM model fits and mnemonic stability are predicted by total CA2/3 volumes. Trial-by-trial retrieval stability within the rOFC and rIFG predicts episodic memory performance, providing a direct neural correlation between hippocampal dysfunction, altered mnemonic representations, and amnesia.eng
dc.identifier.citationMiller, T. D., Hickling, A. L., Wu, Y. I., & Zhou, J. H. et al. (2025). CA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesia. Cell reports, 44(11), Article 116527. https://doi.org/10.1016/j.celrep.2025.116527
dc.identifier.doi10.1016/j.celrep.2025.116527
dc.identifier.issn2211-1247
dc.identifier.other326a9abb-e053-4a03-a22d-99daf8cf1f63
dc.identifier.pmid41217932
dc.identifier.urihttp://hdl.handle.net/10400.14/55822
dc.identifier.wos001618974200002
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCA2/3-dependent stability of frontal mnemonic representations predict episodic deficits in human amnesiaeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.titleCell reports
oaire.citation.volume44
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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