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Chitosan coated textiles may improve atopic dermatitis severity by modulating skin staphylococcal profile: a randomized controlled trial

2015Journal article Open access
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dc.contributor.authorLopes, Cristina
dc.contributor.authorSoares, José
dc.contributor.authorTavaria, Freni
dc.contributor.authorDuarte, Ana
dc.contributor.authorCorreia, Osvaldo
dc.contributor.authorSokhatska, Oksana
dc.contributor.authorSevero, Milton
dc.contributor.authorSilva, Diana
dc.contributor.authorPintado, Manuela
dc.contributor.authorDelgado, Luís
dc.contributor.authorMoreira, André
dc.date.accessioned2016-04-21T13:34:15Z
dc.date.available2016-04-21T13:34:15Z
dc.date.issued2015
dc.description.abstractBackground: Atopic dermatitis (AD) patients may benefit from using textiles coated with skin microbiome-modulating compounds. Chitosan, a natural biopolymer with immunomodulatory and antimicrobial properties, has been considered potentially useful. Objective: This randomized controlled trial assessed the clinical utility of chitosan-coated garment use in AD. Methods: Of the 102 patients screened, 78 adult and adolescents were randomly allocated to overnight use of chitosan-coated or uncoated cotton long-sleeved pyjama tops and pants for 8 weeks. The primary outcome was change in disease severity assessed by Scoring Atopic dermatitis index (SCORAD). Other outcomes were changes in quality of life, pruritus and sleep loss, days with need for rescue medication, number of flares and controlled weeks, and adverse events. Changes in total staphylococci and Staphylococcus aureus skin counts were also assessed. Comparisons were made using analysis of variance supplemented by repeated measures analysis for the primary outcome. Interaction term between time and intervention was used to compare time trends between groups. Results: Chitosan group improved SCORAD from baseline in 43.8%, (95% CI: 30.9 to 55.9), P = 0.01, placebo group in 16.5%(-21.6 to 54.6); P = 0.02 with no significant differences between groups; Dermatology Quality of life Index Score significantly improved in chitosan group (P = 0.02) and a significant increase of skin Coagulase negative Staphylococci (P = 0.02) was seen. Conclusions: Chitosan coated textiles may impact on disease severity by modulating skin staphylococcal profile. Moreover, a potential effect in quality of life may be considered.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationLOPES, Cristina; SOARES, José; TAVARIA, Freni; DUARTE, Ana; CORREIA, Osvaldo; SOKHATSKA, Oksana; SEVERO, Milton; SILVA, Diana; PINTADO, Manuela; DELGADO, Luís; MOREIRA, André - Chitosan Coated Textiles May Improve Atopic Dermatitis Severity by Modulating Skin Staphylococcal Profile: A Randomized Controlled Trial. Plos One. ISSN 1932-6203. Vol. 10, n.º 11 (2015), 14 p. DOI:10.1371/journal.pone.014284pt_PT
dc.identifier.doi10.1371/journal.pone.0142844pt_PT
dc.identifier.eid84957576843
dc.identifier.issn1932-6203
dc.identifier.pmcPMC4664262
dc.identifier.pmid26618557
dc.identifier.urihttp://hdl.handle.net/10400.14/19891
dc.identifier.wos000365889800018
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleChitosan coated textiles may improve atopic dermatitis severity by modulating skin staphylococcal profile: a randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.titlePLoS ONE
oaire.citation.volume10
person.familyNameLopes
person.familyNameKekhasharú Tavaria
person.familyNameSokhatska
person.familyNameSevero
person.familyNamePintado
person.familyNameDelgado
person.familyNameMoreira
person.givenNameCristina
person.givenNameFreni
person.givenNameOksana
person.givenNameMilton
person.givenNameMaria Manuela
person.givenNameLuis
person.givenNameAndré
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person.identifier.orcid0000-0002-7294-9296
person.identifier.ridHOH-4392-2023
person.identifier.ridI-3497-2012
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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