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A comprehensive study into the impact of a chitosan mouthwash upon oral microorganism's biofilm formation in vitro

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dc.contributor.authorCosta, E. M.
dc.contributor.authorSilva, S.
dc.contributor.authorMadureira, A. R.
dc.contributor.authorCardelle-Cobas, A.
dc.contributor.authorTavaria, F.K.
dc.contributor.authorPintado, M. E.
dc.date.accessioned2015-05-15T17:30:45Z
dc.date.available2015-05-15T17:30:45Z
dc.date.issued2014
dc.description.abstractModern dentistry emphasizes the importance of dental plaque control to improve oral health. To that endthe development of oral care formulations has been geared toward the incorporation of antiplaque agentsthat may play a crucial role in oral health maintenance. In later years the research into antiplaque agentshas led to the discovery of compounds with significant capability to affect biofilm formation. Among thesecompounds was chitosan, a polysaccharide which showed great ability to interfere with Streptococcusmutans biofilm formation. As such the aim of this work was to incorporate chitosan into a mouthwashmatrix and assess its effect upon biofilm formation of oral microorganisms. This assessment was per-formed via study of the impact the mouthwash upon microbial adherence, biofilm formation and maturebiofilms. Additionally, the action of the chitosan mouthwash was compared with two commerciallyavailable mouthwashes. The results here obtained show that only the chitosan containing mouthwashwas capable of interfering with all microorganisms’ adherence, biofilm formation and mature biofilmswhile at the same time showing vastly superior activity than both commercial mouthwashes assayed.As such a chitosan mouthwash shows great potential as a natural and efficient alternative to traditionalmouthwashes.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCOSTA, E. M… [et al.] - A comprehensive study into the impact of a chitosan mouthwash upon oral microorganism's biofilm formation in vitro. Carbohydrate Polymers. ISSN 0144-8617. Vol. 101, n.º 1 (2014), p. 1081-1086por
dc.identifier.doi10.1016/j.carbpol.2013.09.041
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10400.14/17620
dc.identifier.wosWOS:000330494800136
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier
dc.relationQREN-ADI 3474
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectChitosanpor
dc.subjectAntibiofilmpor
dc.subjectStreptococcus mutanspor
dc.subjectCandida albicanspor
dc.subjectMouthwashapor
dc.titleA comprehensive study into the impact of a chitosan mouthwash upon oral microorganism's biofilm formation in vitropor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage1086
oaire.citation.startPage1081
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume101
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCosta
person.familyNameSilva
person.familyNameMadureira
person.familyNameCardelle Cobas
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameRaquel
person.givenNameAlejandra
person.givenNameFreni
person.givenNameMaria Manuela
person.identifierM-4659-2013
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0002-0896-9946
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0002-1271-513X
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-4659-2013
person.identifier.ridK-7183-2017
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id9736687700
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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