| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.07 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Modern dentistry emphasizes the importance of dental plaque control to improve oral health. To that endthe development of oral care formulations has been geared toward the incorporation of antiplaque agentsthat may play a crucial role in oral health maintenance. In later years the research into antiplaque agentshas led to the discovery of compounds with significant capability to affect biofilm formation. Among thesecompounds was chitosan, a polysaccharide which showed great ability to interfere with Streptococcusmutans biofilm formation. As such the aim of this work was to incorporate chitosan into a mouthwashmatrix and assess its effect upon biofilm formation of oral microorganisms. This assessment was per-formed via study of the impact the mouthwash upon microbial adherence, biofilm formation and maturebiofilms. Additionally, the action of the chitosan mouthwash was compared with two commerciallyavailable mouthwashes. The results here obtained show that only the chitosan containing mouthwashwas capable of interfering with all microorganisms’ adherence, biofilm formation and mature biofilmswhile at the same time showing vastly superior activity than both commercial mouthwashes assayed.As such a chitosan mouthwash shows great potential as a natural and efficient alternative to traditionalmouthwashes.
Description
Keywords
Chitosan Antibiofilm Streptococcus mutans Candida albicans Mouthwasha
Citation
COSTA, E. M… [et al.] - A comprehensive study into the impact of a chitosan mouthwash upon oral microorganism's biofilm formation in vitro. Carbohydrate Polymers. ISSN 0144-8617. Vol. 101, n.º 1 (2014), p. 1081-1086
Publisher
Elsevier