Publicação
Integrated anatomical and functional connectivity mapping in episodic migraine: a spectral graph theory approach
| dc.contributor.author | Grácio, Gonçalo | |
| dc.contributor.author | Matoso, Ana | |
| dc.contributor.author | Esteves, Inês | |
| dc.contributor.author | Fouto, Ana R. | |
| dc.contributor.author | Ruiz-Tagle, Amparo | |
| dc.contributor.author | Caetano, Gina | |
| dc.contributor.author | Gil-Gouveia, Raquel | |
| dc.contributor.author | Figueiredo, Patrícia | |
| dc.contributor.author | Nunes, Rita G. | |
| dc.contributor.author | Pequito, Sérgio | |
| dc.date.accessioned | 2026-07-03T16:24:35Z | |
| dc.date.available | 2026-07-03T16:24:35Z | |
| dc.date.issued | 2026-05-20 | |
| dc.description.abstract | Migraine disproportionately affects women, yet how migraine physiology reshapes large-scale brain communication remains unclear. We combined diffusion-weighted imaging (DWI) and resting-state fMRI in female participants (14 patients with episodic migraine without aura; 15 matched healthy controls) to test how direct and indirect anatomical communication paths in the brain can predict brain function. We used a spectral mapping framework that isolates the contribution of communication paths of a specific length and evaluated how well brain structure predicts brain function within individuals. Analyses of individual path lengths revealed a non-monotonic dissociation: no difference at one-step (direct) paths, but higher mapping accuracy in patients at intermediate indirect scales (four and five steps). At longer scales, contributions attenuated in both groups. Spatial correspondence analyses localized patient-specific effects to default mode network subsystems across multiple atlases. These findings indicate that migraine-related dysfunction reflects altered mesoscale structure-function integration along indirect anatomical routes, and they provide a general approach to dissect structure-function coupling by communication scale in disease. | eng |
| dc.identifier.doi | 10.1038/s41598-026-53726-7 | |
| dc.identifier.other | e03ec0f9-8586-41de-b096-49efa73f0e8c | |
| dc.identifier.pmid | 42156507 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/58473 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Nature Research | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Integrated anatomical and functional connectivity mapping in episodic migraine: a spectral graph theory approach | |
| dc.type | research article | |
| dspace.entity.type | Publication | |
| oaire.version | http://purl.org/coar/version/c_ab4af688f83e57aa |
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