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Therapeutic insights into Garcinia mangostana: bioactivities, challenges, and future directions in drug discovery

2025-06-30Artigo de investigação Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorAnis, Y.
dc.contributor.authorLabana, R. V.
dc.contributor.authorMendonça, D.
dc.contributor.authorAyunee, S.
dc.contributor.authorDimasin, R. V. D.
dc.contributor.authorBodade, R.
dc.contributor.authorSukati, S.
dc.contributor.authorBoonhok, R.
dc.contributor.authorOliveira, S. M. R.
dc.contributor.authorGirol, A. P.
dc.contributor.authorPereira, M. de Lourdes
dc.contributor.authorChooi-Ling, L.
dc.contributor.authorSamudi, C.
dc.contributor.authorNissapatorn, V.
dc.date.accessioned2025-09-02T14:01:20Z
dc.date.available2025-09-02T14:01:20Z
dc.date.issued2025-06-30
dc.description.abstractGarcinia mangostana is a tropical tree native to India, Sri Lanka, and Southeast Asia. In Traditional Medicinal Systems (TMS), decoctions and infusions prepared from mangosteen fruits have effectively treated skin lesions and various inflammatory conditions. Researchers have also reported its extensive biological activities, viz. antimicrobial, antioxidant, anticancer, antidiabetic, neuroprotective, and cardioprotective effects. This literature review comprehensively describes the biological potential of G. mangostana over the last twenty-five years. It includes a discussion of the bioactive compounds of G. mangostana and their extraction, purification, and characterization processes. Antimicrobial, anticancer, antitumorigenic, antidiabetic, anti-inflammatory, neuroprotective, and antiparasitic activities are discussed in detail. Furthermore, the paper addresses the main obstacles associated with using mangosteen extracts and suggests ways to overcome these challenges. The medicinal properties of G. mangostana are primarily attributed to a-mangostin and other bioactive xanthones. However, other bioactive compounds with potential therapeutic activities remain not fully characterized. Therefore, developing effective extraction methods for these bioactive compounds, along with their characterization, possible bioactivities (pharmacodynamics), and any synergistic effects, is essential. Additionally, pharmacokinetic studies, including absorption, distribution, metabolism, excretion, and toxicity (ADMET), are necessary. It is also worth considering plant parts other than the pericarp.eng
dc.identifier.citationAnis, Y., Labana, R. V., Mendonça, D., & Ayunee, S. et al. (2025). Therapeutic insights into Garcinia mangostana: bioactivities, challenges, and future directions in drug discovery. Tropical Biomedicine, 42(2), 169-183. https://doi.org/10.47665/tb.42.2.010
dc.identifier.doi10.47665/tb.42.2.010
dc.identifier.eid105010670179
dc.identifier.issn0127-5720
dc.identifier.other16427aa6-ed5c-48df-9ec7-b16f70a7a7c7
dc.identifier.pmid40618363
dc.identifier.urihttp://hdl.handle.net/10400.14/54613
dc.identifier.wos001600822300010
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAntimicrobial
dc.subjectBiological activiphytochemicals
dc.subjectBiological products
dc.subjectG. mangostana
dc.subjectNatural products
dc.titleTherapeutic insights into Garcinia mangostana: bioactivities, challenges, and future directions in drug discoveryeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage183
oaire.citation.issue2
oaire.citation.startPage169
oaire.citation.titleTropical Biomedicine
oaire.citation.volume42
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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