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Technological stability of solid lipid nanoparticles loaded with phenolic compounds: drying process and stability along storage

2017Journal article Restricted access
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dc.contributor.authorCampos, Débora A.
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorSarmento, Bruno
dc.contributor.authorPintado, Maria Manuela
dc.contributor.authorGomes, Ana Maria
dc.date.accessioned2017-10-17T13:18:29Z
dc.date.available2017-10-17T13:18:29Z
dc.date.issued2017
dc.description.abstractSolid lipid nanoparticles (SLNs) have been widely studied and tested as vehicles for natural compounds. Recently, Witepsol and Carnauba SLNs were shown to be effective systems for the entrapment of rosmarinic acid (RA) and herbal extracts. In the present work, the improvement of stability and bioactivity of these systems was studied. Thus, the freeze-drying of SLNs produced with Witepsol and Carnauba waxes loaded with RA and herbal extracts (sage and savory) were tested. The use of three different cryoprotectants (glucose, mannitol and trehalose) at two different concentrations (5 and 10%, w/v) were evaluated. Furthermore, the prepared SLNs were stored under different conditions (atmosphere, temperature, absence or presence of light) and in different packaging materials, over 365 days. The effect on the SLNs physical stability and bioactivity was assessed. The most suitable cryoprotectant was mannitol at 10% (w/v) for all formulations tested. The solid state of SLNs, with storage at room temperature, in glass flasks, protected from light and under N2 controlled atmosphere were the best storage conditions in which the SLNs bioactivity was maintained during 365 days.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCAMPOS, Débora A.; MADUREIRA, Ana Raquel; SARMENTO, Bruno; PINTADO, M. E.; GOMES, Ana M. P. - Technological stability of solid lipid nanoparticles loaded with phenolic compounds: Drying process and stability along storage. Journal of Food Engineering. ISSN 0260-8774. Vol. 196 (2017), p. 1-10pt_PT
dc.identifier.doi10.1016/j.jfoodeng.2016.10.009pt_PT
dc.identifier.eid84992193980
dc.identifier.eissn1873-5770
dc.identifier.issn0260-8774
dc.identifier.urihttp://hdl.handle.net/10400.14/23147
dc.identifier.wos000389165200001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.subjectRosmarinic acidpt_PT
dc.subjectSLNspt_PT
dc.subjectWitepsolpt_PT
dc.subjectCarnauba waxpt_PT
dc.subjectFreeze-dryingpt_PT
dc.subjectLong-term stabilitypt_PT
dc.titleTechnological stability of solid lipid nanoparticles loaded with phenolic compounds: drying process and stability along storagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAGR-TEC%2F2227%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FLA0002%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F71391%2F2010/PT
oaire.citation.endPage10
oaire.citation.startPage1
oaire.citation.titleJournal of Food Engineeringpt_PT
oaire.citation.volume196
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamCOMPETE
oaire.fundingStreamCOMPETE
oaire.fundingStreamSFRH
person.familyNameCampos
person.familyNameMadureira
person.familyNameSarmento
person.familyNamePintado
person.familyNameGomes
person.givenNameDébora
person.givenNameRaquel
person.givenNameBruno
person.givenNameMaria Manuela
person.givenNameAna Maria
person.identifierD-8675-2016
person.identifierM-4659-2013
person.identifier152609
person.identifier456608
person.identifier162628
person.identifier.ciencia-id1A16-FC5B-3468
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-idAA12-BFC1-B2E3
person.identifier.orcid0000-0003-0174-6640
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0001-7883-2446
person.identifier.ridM-4659-2013
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.ridB-9944-2013
person.identifier.scopus-author-id55250923400
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id57190668768
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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