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Hybrid computational modelling of human voltage-gated sodium channels for isoform-specific therapeutic design
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Introduction: Voltage-gated sodium channels are membrane proteins that open and close in response to voltage changes to allow Na+ influx in excitable cells, enabling action potentials, muscle contraction, and electrical signaling. Aim: Apply a hybrid modelling strategy that combines artificial intelligence and physics-based refinement to build a realistic 3D models of NaV channels.