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Optimization of two biopolymer-based oral films for the delivery of bioactive molecules

2017Journal article Restricted access
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dc.contributor.authorCastro, Pedro M.
dc.contributor.authorFonte, Pedro
dc.contributor.authorOliveira, Ana
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorSarmento, Bruno
dc.contributor.authorPintado, Manuela E.
dc.date.accessioned2017-12-12T18:25:28Z
dc.date.available2017-12-12T18:25:28Z
dc.date.issued2017
dc.description.abstractAn experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of bioactive compounds. Carboxymethylcellulose (CMC) and gelatin type A (GelTA) were selected as polymeric matrix. Scanning electron microscopy revealed that caffeine crystals were homogeneously dispersed onto oral film matrix. Fourier-transform infrared analysis did not indicate formation of new chemical entities. USP modified dissolution assay revealed that GelTA was more effective in controlling caffeine release since maximum caffeine release (97.4%±0.95) after 20min. On the other hand, CMC is better indicated for immediate release since maximum caffeine release (81.1%±2.14) occurred after 4min. Simulation of gastrointestinal tract with ex vivo permeability assay was in accordance with USP dissolution assay (42.0%±7.79 and 15.3%±4.0 of caffeine released from CMC and GelTA oral films (OF), respectively, permeated porcine intestinal mucosa after 120min). CMCOF and GelTAOF optimized formulations represent two suitable oral delivery systems for immediate and controlled release, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastro, P. M., Fonte, P., Oliveira, A., Madureira, A. R., Sarmento, B., Pintado, M. E. (2017). Optimization of two biopolymer-based oral films for the delivery of bioactive molecules. Materials Science & Engineering C-Materials for Biological Applications, 76, 171-180pt_PT
dc.identifier.doi10.1016/j.msec.2017.02.173pt_PT
dc.identifier.eid85015419486
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pmid28482514
dc.identifier.urihttp://hdl.handle.net/10400.14/23662
dc.identifier.wos000405541600021
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNORTE-07-0162-FEDER-00010pt_PT
dc.relationDevelopment of oral strips containing nanoencapsulated bioactive compounds
dc.subjectCaffeinept_PT
dc.subjectCarboxymethylcellulosept_PT
dc.subjectGelatin type Apt_PT
dc.subjectOral deliverypt_PT
dc.subjectOral filmspt_PT
dc.subjectNutraceuticalpt_PT
dc.titleOptimization of two biopolymer-based oral films for the delivery of bioactive moleculespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of oral strips containing nanoencapsulated bioactive compounds
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-NAN%2F3249%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F78127%2F2011/PT
oaire.citation.endPage180
oaire.citation.startPage171
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume76
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameMiranda de Castro
person.familyNameFonte
person.familyNameOliveira
person.familyNameMadureira
person.familyNameSarmento
person.familyNamePintado
person.givenNamePedro João
person.givenNamePedro
person.givenNameAna
person.givenNameRaquel
person.givenNameBruno
person.givenNameMaria Manuela
person.identifier1415634
person.identifierM-4659-2013
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person.identifier.ciencia-id5112-6B99-DC1F
person.identifier.ciencia-id2410-123D-3385
person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-idE816-B6B0-06A5
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person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0002-1115-9282
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridK-3215-2013
person.identifier.ridJ-3404-2013
person.identifier.ridM-4659-2013
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id55146900200
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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