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Dispersive liquid–liquid microextraction and HPLC to analyse fluoxetine and metoprolol enantiomers in wastewaters

2015Journal article Restricted access
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dc.contributor.authorRibeiro, Ana R.
dc.contributor.authorGonçalves, Virgínia M. F.
dc.contributor.authorMaia, Alexandra S.
dc.contributor.authorRibeiro, Cláudia
dc.contributor.authorCastro, Paula M. L.
dc.contributor.authorTiritan, Maria E.
dc.date.accessioned2016-04-21T15:19:00Z
dc.date.available2016-04-21T15:19:00Z
dc.date.issued2015
dc.description.abstractSample extraction is a major step in environmental analyses due both to the high complexity of matrices and to the low concentration of the target analytes. Sample extraction is usually expensive, laborious, time-consuming and requires a high amount of organic solvents. Actually, there is a lack of miniaturized methodologies for sample extraction and chiral analyses. Here, we developed a dispersive liquid-liquid microextraction (DLLME) to extract the pharmaceuticals fluoxetine and metoprolol, as models of basic chiral compounds, from wastewater samples. Compounds were then analysed by enantioselective high-performance liquid chromatography. We monitored the influence of sample pH, extracting and dispersive solvent and respective volumes, salt addition, extracting and vortexing time. The DLLME method was validated within the range of 1-10 A mu g L-1 for fluoxetine enantiomers and 0.5-10 A mu g L-1 for metoprolol enantiomers. Accuracy ranged from 90.6 to 106 % and recovery rates from 54.5 to 81.5 %. Relative standard deviation values lower than 7.84 and 9.00 % were obtained for intra- and inter-batch precision, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationRIBEIRO, Ana R.; GONÇALVES, Virgínia M. F.; MAIA, Alexandra S.; RIBEIRO, Cláudia; CASTRO, Paula M.L.; TIRITAN, Maria E. - Dispersive liquid–liquid microextraction and HPLC to analyse fluoxetine and metoprolol enantiomers in wastewaters. Environmental Chemistry Letters. ISSN. 1610-3653. Vol. 13 (2015), 203–210pt_PT
dc.identifier.doi10.1007/s10311-015-0498-2
dc.identifier.eid84939966657
dc.identifier.eissn1610-3661
dc.identifier.issn1610-3653
dc.identifier.urihttp://hdl.handle.net/10400.14/19913
dc.identifier.wos000354721700007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer
dc.relationCEQUIMED-PEst-OE/SAU/UI4040/2014
dc.relationFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
dc.subjectDispersive liquid–liquid microextractionpt_PT
dc.subjectSample preparationpt_PT
dc.subjectHPLC-FDpt_PT
dc.subjectChiral pharmaceuticalspt_PT
dc.subjectChirobiotic Vpt_PT
dc.subjectWastewaterspt_PT
dc.titleDispersive liquid–liquid microextraction and HPLC to analyse fluoxetine and metoprolol enantiomers in wastewaterspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64999%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86939%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEBB-EBI%2F111699%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.citation.endPage210
oaire.citation.issue2
oaire.citation.startPage203
oaire.citation.titleEnvironmental Chemistry Letters
oaire.citation.volume13
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameFerreira Gonçalves
person.familyNameMaia
person.familyNameRibeiro
person.familyNameCastro
person.familyNameTiritan
person.givenNameVirgínia Maria
person.givenNameAlexandra S.
person.givenNameClaudia
person.givenNamePaula
person.givenNameMaria Elizabeth
person.identifier2013444
person.identifier1310409
person.identifier.ciencia-idDB12-D51F-C2D7
person.identifier.ciencia-id6A15-F0A3-AEF2
person.identifier.ciencia-id9D17-0C17-2703
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.orcid0000-0002-9151-516X
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0001-7245-4552
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0003-3320-730X
person.identifier.ridM-8241-2013
person.identifier.ridK-9492-2014
person.identifier.scopus-author-id23097687200
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id56835095200
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id6602890981
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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