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Biocompatibility and effectiveness of a novel, organic olive oil-based denture adhesive: a multicenter randomized and placebo-controlled clinical trial

2021-04-01Journal article Open access
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dc.contributor.authorAzevedo, Luís
dc.contributor.authorCorreia, André
dc.contributor.authorAlmeida, Carlos F.
dc.contributor.authorMolinero-Mourelle, Pedro
dc.contributor.authorCorreia, Maria
dc.contributor.authorHighsmith, Jaime del Río
dc.date.accessioned2021-04-05T15:53:40Z
dc.date.available2021-04-05T15:53:40Z
dc.date.issued2021-04-01
dc.description.abstractTo assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijerph18073398pt_PT
dc.identifier.eid85103062635
dc.identifier.issn1661-7827
dc.identifier.pmcPMC8036724
dc.identifier.pmid33805975
dc.identifier.urihttp://hdl.handle.net/10400.14/32448
dc.identifier.wos000638519000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicro-bial activitypt_PT
dc.subjectCandida albicanspt_PT
dc.subjectComplete denturespt_PT
dc.subjectEdentulismpt_PT
dc.subjectElderlypt_PT
dc.subjectProsthodonticspt_PT
dc.titleBiocompatibility and effectiveness of a novel, organic olive oil-based denture adhesive: a multicenter randomized and placebo-controlled clinical trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume18pt_PT
person.familyNameAzevedo
person.familyNameCorreia
person.familyNameMolinero-Mourelle
person.familyNameCorreia
person.givenNameLuís
person.givenNameAndre
person.givenNamePedro
person.givenNameMaria
person.identifierR-000-NAN
person.identifier283619
person.identifier.ciencia-idDC19-CAE4-44C1
person.identifier.ciencia-idC511-A84D-54AE
person.identifier.orcid0000-0001-9984-653X
person.identifier.orcid0000-0002-0119-9790
person.identifier.orcid0000-0001-5493-0295
person.identifier.orcid0000-0002-6141-9089
person.identifier.ridA-5330-2010
person.identifier.ridM-6028-2017
person.identifier.ridH-9952-2012
person.identifier.scopus-author-id57202864930
person.identifier.scopus-author-id55418261400
person.identifier.scopus-author-id57191893109
person.identifier.scopus-author-id7102145871
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication80810ed0-f9f2-4f0f-9192-e8b718d54be3
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relation.isAuthorOfPublication.latestForDiscovery80810ed0-f9f2-4f0f-9192-e8b718d54be3

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