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Prognostic role and clinicopathological features of SMAD4 gene mutation in pancreatic cancer: a systematic review and meta-analysis

2026-01-01Artigo de revisão Acesso aberto
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dc.contributor.authorRodrigues, Tânia
dc.contributor.authorAlbuquerque, Joana
dc.contributor.authorCardoso, Joana
dc.contributor.authorSousa-Ferreira, Ivo
dc.contributor.authorMartins, João Paulo
dc.contributor.authorCoelho, José Luís Passos
dc.date.accessioned2026-02-06T10:29:34Z
dc.date.available2026-02-06T10:29:34Z
dc.date.issued2026-01-01
dc.description.abstractPurpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in pancreatic cancer to aid in the design of therapeutic strategies. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and the proposed methodology was registered on PROSPERO. An electronic search was made in MEDLINE (via PubMed), Web of Science and Google Scholar to identify all relevant studies. Eligible studies were those written in English including patients with Pancreatic Ductal Adenocarcinoma (PDAC), who underwent pancreatic surgery with curative intent and provided data on SMAD4 gene status or SMAD4 protein expression and its association to prognosis, measured by overall survival (OS). The effect measure of interest was the hazard ratio (HR) for OS between PDAC with or without SMDA4 mutations. Results: A total of 24 studies on SMAD4, with 4340 samples, were included in this systematic review and meta-analysis. Our pooled results demonstrated that patients with tumours with SMAD4 alteration had significantly worse prognosis for OS (HR= 1.43, 95% CI = 1.17–1.76, p-value = 0.002). Conclusion: This systematic review and meta-analysis support the use of driver mutations in the SMAD4 gene as a prognostic marker for pancreatic cancer.eng
dc.identifier.citationRodrigues, T., Albuquerque, J., Cardoso, J., & Sousa-Ferreira, I. et al. (2026). Prognostic role and clinicopathological features of SMAD4 gene mutation in pancreatic cancer: a systematic review and meta-analysis. Cancer Treatment and Research Communications, 46, Article 101091. https://doi.org/10.1016/j.ctarc.2025.101091
dc.identifier.doi10.1016/j.ctarc.2025.101091
dc.identifier.eid105028423821
dc.identifier.issn2213-0896
dc.identifier.othera1422626-a7c6-4c0c-a8a4-3049c0db2738
dc.identifier.pmid41576526
dc.identifier.urihttp://hdl.handle.net/10400.14/56947
dc.identifier.wos001677470600001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectImmunohistochemistry
dc.subjectMutation
dc.subjectPancreatic cancer (PDAC)
dc.subjectPrognostic
dc.subjectSMAD4 gene
dc.subjectSMAD4 protein
dc.titlePrognostic role and clinicopathological features of SMAD4 gene mutation in pancreatic cancer: a systematic review and meta-analysiseng
dc.typereview article
dspace.entity.typePublication
oaire.citation.titleCancer Treatment and Research Communications
oaire.citation.volume46
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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