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Anti-inflammatory activity of chitooligosaccharides in vivo

dc.contributor.authorFernandes, João C.
dc.contributor.authorSpindola, Humberto
dc.contributor.authorSousa, Vanessa de
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorMalcata, Francisco Xavier
dc.contributor.authorCarvalho, João E.
dc.date.accessioned2023-03-22T11:58:32Z
dc.date.available2023-03-22T11:58:32Z
dc.date.issued2010-06
dc.description.abstractAll the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md8061763pt_PT
dc.identifier.eid77954239729
dc.identifier.issn1660-3397
dc.identifier.pmcPMC2901823
dc.identifier.pmid20631868
dc.identifier.urihttp://hdl.handle.net/10400.14/40675
dc.identifier.wos000280347000004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectChitooligosaccharidespt_PT
dc.titleAnti-inflammatory activity of chitooligosaccharides in vivopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1768pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1763pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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