Publication
Anti-inflammatory activity of chitooligosaccharides in vivo
| dc.contributor.author | Fernandes, João C. | |
| dc.contributor.author | Spindola, Humberto | |
| dc.contributor.author | Sousa, Vanessa de | |
| dc.contributor.author | Santos-Silva, Alice | |
| dc.contributor.author | Pintado, Manuela E. | |
| dc.contributor.author | Malcata, Francisco Xavier | |
| dc.contributor.author | Carvalho, João E. | |
| dc.date.accessioned | 2023-03-22T11:58:32Z | |
| dc.date.available | 2023-03-22T11:58:32Z | |
| dc.date.issued | 2010-06 | |
| dc.description.abstract | All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatory activity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/md8061763 | pt_PT |
| dc.identifier.eid | 77954239729 | |
| dc.identifier.issn | 1660-3397 | |
| dc.identifier.pmc | PMC2901823 | |
| dc.identifier.pmid | 20631868 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/40675 | |
| dc.identifier.wos | 000280347000004 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Animal model | pt_PT |
| dc.subject | Anti-inflammatory | pt_PT |
| dc.subject | Chitooligosaccharides | pt_PT |
| dc.title | Anti-inflammatory activity of chitooligosaccharides in vivo | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1768 | pt_PT |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | 1763 | pt_PT |
| oaire.citation.title | Marine Drugs | pt_PT |
| oaire.citation.volume | 8 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |