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Comparative in silico docking of bioactive peptides across the gut-skin axis: a systems approach to psoriasis modulation via the host-microbe interactions

2025-12-05Documento de conferência Acesso embargado
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSilva, Isa
dc.contributor.authorLambert, Jo L. W.
dc.contributor.authorPintado, Manuela
dc.contributor.authorCoscueta, Ezequiel R.
dc.date.accessioned2026-01-30T11:40:15Z
dc.date.available2026-01-30T11:40:15Z
dc.date.issued2025-12-05
dc.description.abstractIntroduction: Psoriasis and inflammatory bowel disease (IBD) are chronic immune-mediated disorders sharing epithelial barrier dysfunction, dysbiosis, and sustained pro-inflammatory signaling. The gut–skin axis represents a network of host–microbe interactions, where microbial metabolites and immune responses shape inflammation in both intestinal and cutaneous environments.1 Bioactive peptides (BPeps) from natural sources are promising immunomodulators that may restore barrier integrity and attenuate key pathways such as NF-?B, JAK/STAT, and MAPK.2 Given this complex interplay, molecular docking was applied as an in silico strategy to prioritize peptide–protein interactions for in vitro validation.eng
dc.identifier.citationSilva, I., Lambert, J. L. W., Pintado, M., & Coscueta, E. R. (2025). Comparative in silico docking of bioactive peptides across the gut-skin axis: a systems approach to psoriasis modulation via the host-microbe interactions. 1-2. Abstract from III ImmunoHub ERA Chair Annual Meeting, Porto, Portugal.
dc.identifier.other11a41bf1-c4bc-4ae1-b657-fe5a9823e6ca
dc.identifier.urihttp://hdl.handle.net/10400.14/56812
dc.language.isoeng
dc.peerreviewedyes
dc.rights.uriN/A
dc.subjectBioactive peptides
dc.subjectGut-skin axis
dc.subjectInflammation
dc.subjectMolecular docking
dc.subjectPsoriasis
dc.titleComparative in silico docking of bioactive peptides across the gut-skin axis: a systems approach to psoriasis modulation via the host-microbe interactionseng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage2
oaire.citation.startPage1
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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