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Assessment of copper and zinc salts as selectors of antibiotic resistance in Gram-negative bacteria

2015Journal article Restricted access
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dc.contributor.authorBecerra-Castro, Cristina
dc.contributor.authorMachado, Rita A.
dc.contributor.authorVaz-Moreira, Ivone
dc.contributor.authorManaia, Célia M.
dc.date.accessioned2016-04-21T14:10:59Z
dc.date.available2016-04-21T14:10:59Z
dc.date.issued2015
dc.description.abstractSome metals are nowadays considered environmental pollutants. Although some, like Cu and Zn, are essential for microorganisms, at high concentrations they can be toxic or exert selective pressures on bacteria. This study aimed to assess the potential of Cu or Zn as selectors of specific bacterial populations thriving in wastewater. Populations of Escherichia coli recovered on metal-free and metal-supplemented culture medium were compared based on antibiotic resistance phenotype and other traits. In addition, the bacterial groups enriched after successive transfers in metal-supplemented culture medium were identified. At a concentration of 1 mM, Zn produced a stronger inhibitory effect than Cu on the culturability of Enterobacteriaceae. It was suggested that Zn selected populations with increased resistance prevalence to sulfamethoxazole or ciprofloxacin. In non-selective culture media, Zn or Cu selected for mono-species populations of ubiquitous Betaproteobacteria and Flavobacteriia, such as Ralstonia pickettii or Elizabethkingia anophelis, yielding multidrug resistance profiles including resistance against carbapenems and third generation cephalosporins, confirming the potential of Cu or Zn as selectors of antibiotic resistant bacteria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationBECERRA-CASTRO, Cristina ...[et al.] - Assessment of copper and zinc salts as selectors of antibiotic resistance in Gram-negative bacteria. Science of the Total Environment. ISSN 0048-9697. Vol. 530–531 (2015), p. 367–372pt_PT
dc.identifier.doi10.1016/j.scitotenv.2015.05.102
dc.identifier.eid84931292234
dc.identifier.eissn1879-1026
dc.identifier.issn0048-9697
dc.identifier.pmid26057541
dc.identifier.urihttp://hdl.handle.net/10400.14/19897
dc.identifier.wos000356605800041
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.relationDYNAMICS OF ANTIMICROBIAL RESISTANCE BETWEEN THE HOSPITAL AND THE ENVIRONMENT
dc.relationRELATIONSHIP BETWEEN METAL AND ANTIBIOTIC RESISTANCE: IMPLICATIONS IN AGRICULTURAL CROPS
dc.subjectAntibiotic resistance selectorspt_PT
dc.subjectMetalspt_PT
dc.subjectSelective pressurept_PT
dc.subjectWastewaterpt_PT
dc.subjectE. colipt_PT
dc.titleAssessment of copper and zinc salts as selectors of antibiotic resistance in Gram-negative bacteriapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDYNAMICS OF ANTIMICROBIAL RESISTANCE BETWEEN THE HOSPITAL AND THE ENVIRONMENT
oaire.awardTitleRELATIONSHIP BETWEEN METAL AND ANTIBIOTIC RESISTANCE: IMPLICATIONS IN AGRICULTURAL CROPS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAAC-AMB%2F113840%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F87152%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F87360%2F2012/PT
oaire.citation.endPage372
oaire.citation.startPage367
oaire.citation.volume530-531
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameBecerra-Castro
person.familyNameVaz-Moreira
person.familyNameManaia
person.givenNameCristina
person.givenNameIvone
person.givenNameCélia
person.identifier602434
person.identifier.ciencia-id9E17-544E-800D
person.identifier.ciencia-idC31F-553B-6365
person.identifier.orcid0000-0003-0347-4992
person.identifier.orcid0000-0001-8912-9836
person.identifier.orcid0000-0002-3674-1789
person.identifier.scopus-author-id35168353700
person.identifier.scopus-author-id16044425800
person.identifier.scopus-author-id6602465318
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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