Logo do repositório
 
Publicação

Antimicrobial properties of gallium (III)-and iron (III)-loaded polysaccharides affecting the growth of escherichia coli, staphylococcus aureus, and pseudomonas aeruginosa, in vitro

2020Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorBest, Mark G.
dc.contributor.authorCunha-Reis, Cassilda
dc.contributor.authorGanin, Alexey Y.
dc.contributor.authorSousa, Aureliana
dc.contributor.authorJohnston, Jenna
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorSmith, David G. E.
dc.contributor.authorYiu, Humphrey H. P.
dc.contributor.authorCooper, Ian R.
dc.date.accessioned2021-01-28T16:28:07Z
dc.date.available2021-01-28T16:28:07Z
dc.date.issued2020
dc.description.abstractAntimicrobial resistance (AMR) has become a global concern as many bacterial species have developed resistance to commonly prescribed antibiotics, making them ineffective to treatments. One type of antibiotics, gallium(III) compounds, stands out as possible candidates due to their unique “Trojan horse” mechanism to tackle bacterial growth, by substituting iron(III) in the metabolic cycles of bacteria. In this study, we tested three polysaccharides (carboxymethyl cellulose (CMC), alginate, and pectin) as the binding and delivery agent for gallium on three bacteria (Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus) with a potential bioresponsive delivery mode. Two types of analysis on bacterial growth (minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC)) were carried out while iron(III)-loaded polysaccharide samples were also tested for comparison. The results suggested that gallium showed an improved inhibitory activity on bacterial growth, in particular gallium(III)-loaded carboxymethyl cellulose (Ga-CMC) sample showing an inhibiting effect on growth for all three tested bacteria. At the MIC for all three bacteria, Ga-CMC showed no cytotoxicity effect on human dermal neonatal fibroblasts (HDNF). Therefore, these bioresponsive gallium(III) polysaccharide compounds show significant potential to be developed as the next-generation antibacterial agents with controlled release capability.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationBest, M. G., Cunha-Reis, C., Ganin, A. Y., Sousa, A., Johnston, J., Oliveira, A. L., ... Cooper, I. R. (2020). Antimicrobial properties of gallium (III)-and iron (III)-loaded polysaccharides affecting the growth of escherichia coli, staphylococcus aureus, and pseudomonas aeruginosa, in vitro. ACS Applied Bio Materialspt_PT
dc.identifier.doi10.1021/acsabm.0c00811pt_PT
dc.identifier.eid85094585663
dc.identifier.issn2576-6422
dc.identifier.urihttp://hdl.handle.net/10400.14/31812
dc.identifier.wos000604607600032
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.subjectGalliumpt_PT
dc.subjectCarbohydratespt_PT
dc.subjectAntibacterialpt_PT
dc.subjectAntibioticspt_PT
dc.subjectAnaerobicpt_PT
dc.titleAntimicrobial properties of gallium (III)-and iron (III)-loaded polysaccharides affecting the growth of escherichia coli, staphylococcus aureus, and pseudomonas aeruginosa, in vitropt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleACS Applied Bio Materialspt_PT
person.familyNameCunha Reis
person.familyNameGanin
person.familyNameSousa
person.familyNameOliveira
person.givenNameCassilda
person.givenNameAlexey
person.givenNameAureliana
person.givenNameAna
person.identifier1415634
person.identifier.ciencia-idE718-0A09-A959
person.identifier.ciencia-id4218-C2C4-3A68
person.identifier.ciencia-id4713-31C8-A356
person.identifier.orcid0000-0001-6886-3900
person.identifier.orcid0000-0002-3754-5819
person.identifier.orcid0000-0003-2191-8892
person.identifier.orcid0000-0001-8012-4203
person.identifier.ridG-6286-2014
person.identifier.ridJ-3404-2013
person.identifier.scopus-author-id20336729000
person.identifier.scopus-author-id15132006500
person.identifier.scopus-author-id35345790700
person.identifier.scopus-author-id55937245800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3000922a-5ab0-4d36-8fd3-e88bfca427f1
relation.isAuthorOfPublication7889b0f2-3d58-45c3-a75f-3b23a3fca8b4
relation.isAuthorOfPublication65fe8784-c818-4dd3-94d2-d015c74b4790
relation.isAuthorOfPublication87934068-f621-402f-b5e6-93e492526ced
relation.isAuthorOfPublication.latestForDiscovery65fe8784-c818-4dd3-94d2-d015c74b4790

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
27400883.pdf
Tamanho:
970.54 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

CBQF - Contribuições em Revistas Científicas / Contribution to Journals