Publicação
Synthesis of bio-based Polyester from microbial lipidic residue intended for biomedical application
| dc.contributor.author | Capêto, Ana P. | |
| dc.contributor.author | Azevedo-Silva, João | |
| dc.contributor.author | Sousa, Sérgio | |
| dc.contributor.author | Pintado, Manuela | |
| dc.contributor.author | Guimarães, Ana S. | |
| dc.contributor.author | Oliveira, Ana L. S. | |
| dc.date.accessioned | 2023-03-02T14:41:17Z | |
| dc.date.available | 2023-03-02T14:41:17Z | |
| dc.date.issued | 2023-02-23 | |
| dc.description.abstract | In the last decade, selectively tuned bio-based polyesters have been increasingly used for their clinical potential in several biomedical applications, such as tissue engineering, wound healing, and drug delivery. With a biomedical application in mind, a flexible polyester was produced by melt polycondensation using the microbial oil residue collected after the distillation of β-farnesene (FDR) produced industrially by genetically modified yeast, Saccharomyces cerevisiae. After characterization, the polyester exhibited elongation up to 150% and presented Tg of −51.2 °C and Tm of 169.8 °C. In vitro degradation revealed a mass loss of about 87% after storage in PBS solution for 11 weeks under accelerated conditions (40 °C, RH = 75%). The water contact angle revealed a hydrophilic character, and biocompatibility with skin cells was demonstrated. 3D and 2D scaffolds were produced by salt-leaching, and a controlled release study at 30 °C was performed with Rhodamine B base (RBB, 3D) and curcumin (CRC, 2D), showing a diffusion-controlled mechanism with about 29.3% of RBB released after 48 h and 50.4% of CRC after 7 h. This polymer offers a sustainable and eco-friendly alternative for the potential use of the controlled release of active principles for wound dressing applications. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/ijms24054419 | pt_PT |
| dc.identifier.eid | 85149850572 | |
| dc.identifier.issn | 1661-6596 | |
| dc.identifier.pmid | 36901850 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/40417 | |
| dc.identifier.wos | 000948207700001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Microbial oil | pt_PT |
| dc.subject | Bio-based polyester | pt_PT |
| dc.subject | Biocompatible | pt_PT |
| dc.subject | Hydrophilic | pt_PT |
| dc.subject | Wound dressing | pt_PT |
| dc.subject | Drug delivery | pt_PT |
| dc.title | Synthesis of bio-based Polyester from microbial lipidic residue intended for biomedical application | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 19 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 1 | pt_PT |
| oaire.citation.title | International Journal of Molecular Sciences | pt_PT |
| oaire.citation.volume | 24 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |