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Exosomal aβ-binding proteins identified by “in silico” analysis represent putative blood-derived biomarker candidates for alzheimer´s disease

2021-04-11Journal article Open access
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dc.contributor.authorMartins, Tânia Soares
dc.contributor.authorMarçalo, Rui
dc.contributor.authorFerreira, Maria
dc.contributor.authorVaz, Margarida
dc.contributor.authorSilva, Raquel M.
dc.contributor.authorRosa, Ilka Martins
dc.contributor.authorVogelgsang, Jonathan
dc.contributor.authorWiltfang, Jens
dc.contributor.authorSilva, Odete A. B. da Cruz e
dc.contributor.authorHenriques, Ana Gabriela
dc.date.accessioned2021-04-27T11:33:17Z
dc.date.available2021-04-27T11:33:17Z
dc.date.issued2021-04-11
dc.description.abstractThe potential of exosomes as biomarker resources for diagnostics and even for therapeutics has intensified research in the field, including in the context of Alzheimer´s disease (AD). The search for disease biomarkers in peripheral biofluids is advancing mainly due to the easy access it offers. In the study presented here, emphasis was given to the bioinformatic identification of putative exosomal candidates for AD. The exosomal proteomes of cerebrospinal fluid (CSF), serum and plasma, were obtained from three databases (ExoCarta, EVpedia and Vesiclepedia), and complemented with additional exosomal proteins already associated with AD but not found in the databases. The final biofluids’ proteomes were submitted to gene ontology (GO) enrichment analysis and the exosomal Aβ-binding proteins that can constitute putative candidates were identified. Among these candidates, gelsolin, a protein known to be involved in inhibiting Abeta fibril formation, was identified, and it was tested in human samples. The levels of this Aβ-binding protein, with anti-amyloidogenic properties, were assessed in serum-derived exosomes isolated from controls and individuals with dementia, including AD cases, and revealed altered expression patterns. Identification of potential peripheral biomarker candidates for AD may be useful, not only for early disease diagnosis but also in drug trials and to monitor disease progression, allowing for a timely therapeutic intervention, which will positively impact the patient’s quality of life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms22083933pt_PT
dc.identifier.eid85103848087
dc.identifier.issn1661-6596
dc.identifier.pmcPMC8070602
dc.identifier.pmid33920336
dc.identifier.urihttp://hdl.handle.net/10400.14/32756
dc.identifier.wos000644305600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAbeta binding proteinspt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectBiomarkerpt_PT
dc.subjectDiagnosispt_PT
dc.subjectExosomespt_PT
dc.titleExosomal aβ-binding proteins identified by “in silico” analysis represent putative blood-derived biomarker candidates for alzheimer´s diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume22pt_PT
person.familyNameSilva
person.familyNameWiltfang
person.familyNameda Cruz e Silva
person.familyNameHenriques
person.givenNameRaquel
person.givenNameJens
person.givenNameOdete A. B.
person.givenNameAna Gabriela
person.identifier121481
person.identifier5137
person.identifier366605
person.identifier.ciencia-id4013-2B06-031F
person.identifier.ciencia-idCC14-8DED-2DBF
person.identifier.ciencia-idB51F-B148-95B3
person.identifier.ciencia-idB318-063D-E080
person.identifier.orcid0000-0001-5926-8042
person.identifier.orcid0000-0003-1492-5330
person.identifier.orcid0000-0003-3718-9874
person.identifier.orcid0000-0003-0851-6979
person.identifier.ridB-8337-2008
person.identifier.ridF-4072-2010
person.identifier.ridF-8414-2011
person.identifier.scopus-author-id55209561400
person.identifier.scopus-author-id7006535248
person.identifier.scopus-author-id6603417640
person.identifier.scopus-author-id7102209466
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationf04e66a9-c092-49fd-87b8-cb41ed64f20d
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relation.isAuthorOfPublication.latestForDiscoveryf04e66a9-c092-49fd-87b8-cb41ed64f20d

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