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The effect of flaxseed in breast cancer: a literature review

2018-02-07Journal article Open access
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dc.contributor.authorCalado, Ana
dc.contributor.authorNeves, Pedro Miguel
dc.contributor.authorSantos, Teresa
dc.contributor.authorRavasco, Paula
dc.date.accessioned2021-04-16T14:26:42Z
dc.date.available2021-04-16T14:26:42Z
dc.date.issued2018-02-07
dc.description.abstractBreast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fnut.2018.00004pt_PT
dc.identifier.eid85051957760
dc.identifier.issn2296-861X
dc.identifier.pmid29468163
dc.identifier.urihttp://hdl.handle.net/10400.14/32674
dc.identifier.wos000427135700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectFlaxseedpt_PT
dc.subjectLignanpt_PT
dc.subjectNutritionpt_PT
dc.subjectOmega-3pt_PT
dc.titleThe effect of flaxseed in breast cancer: a literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Nutritionpt_PT
oaire.citation.volume5pt_PT
person.familyNameNeves
person.familyNameRavasco
person.givenNamePedro
person.givenNamePaula
person.identifier459262
person.identifier381093
person.identifier.ciencia-id0219-A80A-F201
person.identifier.ciencia-id2E1E-155A-9B23
person.identifier.orcid0000-0002-8641-8859
person.identifier.orcid0000-0002-6056-8269
person.identifier.scopus-author-id57206372653
person.identifier.scopus-author-id6602551513
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8860989d-7649-4eec-9a9e-6a85e1139f47
relation.isAuthorOfPublication2c8ebd2c-2f6d-4a0b-9271-dbe40af19875
relation.isAuthorOfPublication.latestForDiscovery8860989d-7649-4eec-9a9e-6a85e1139f47

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