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Rat olfactory mucosa mesenchymal stem/stromal cells (om-mscs): a characterization study

2020Journal article Open access
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dc.contributor.authorAlvites, Rui D.
dc.contributor.authorBranquinho, Mariana V.
dc.contributor.authorCaseiro, Ana R.
dc.contributor.authorAmorim, Irina
dc.contributor.authorPedrosa, Sílvia Santos
dc.contributor.authorRêma, Alexandra
dc.contributor.authorFaria, Fátima
dc.contributor.authorPorto, Beatriz
dc.contributor.authorOliveira, Cláudia
dc.contributor.authorTeixeira, Paula
dc.contributor.authorMagalhães, Rui
dc.contributor.authorGeuna, Stefano
dc.contributor.authorVarejão, Artur S. P.
dc.contributor.authorMaurício, Ana C.
dc.date.accessioned2020-04-17T14:04:32Z
dc.date.available2020-04-17T14:04:32Z
dc.date.issued2020
dc.description.abstractStem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associated ethical issues. These cells are easily accessible in the nasal cavity of most mammals, including the rat, can be easily applied in autologous treatments, and do not cope with most of the obstacles associated with the use of other stem cells. Despite this, its application in preclinical trials and in both human and animal patients is still limited because of the small number of studies performed so far and to the nonexistence of a standard and unambiguous protocol for collection, isolation, and therapeutic application. In the present work a validation of a protocol for isolation, culture, expansion, freezing, and thawing of olfactory mucosa mesenchymal stem/stromal cells was performed, applied to the rat model, as well as a biological characterization of these cells. To investigate the therapeutic potential of OM-MSCs and their eventual safe application in preclinical trials, the main characteristics of OMSC stemness were addressed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlvites, R. D., Branquinho, M. V., Caseiro, A. R., Amorim, I., Santos Pedrosa, S., Rêma, A., ..., Magalhães, R. (2020). Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM-MSCs): A Characterization Study. International Journal of Cell Biologypt_PT
dc.identifier.doi10.1155/2020/2938258pt_PT
dc.identifier.eid85079295088
dc.identifier.eissn1687-8884
dc.identifier.issn1687-8876
dc.identifier.pmcPMC7212324
dc.identifier.pmid32411249
dc.identifier.urihttp://hdl.handle.net/10400.14/30279
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawipt_PT
dc.relationNORTE-01-0247-FEDER-003262pt_PT
dc.relationStrategic Project - UI 211 - 2011-2012
dc.relationStrategic Project - UI 285 - 2013-2014
dc.relationBioMaTE - A novel bio-manufacturing system to produce bioactive scaffolds for tissue engineering
dc.relationSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practice alterado para: “Cell-based Therapies in Regenerative Medicine – The therapeuthic potential of Umbilical Cord and Dental Pulp derived Stem / Stromal Cells”
dc.relationCombined use of olfactory mucosa mesenchymal stem cells and biomaterials in regenerative therapies after peripheral nerve injury
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleRat olfactory mucosa mesenchymal stem/stromal cells (om-mscs): a characterization studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 211 - 2011-2012
oaire.awardTitleStrategic Project - UI 285 - 2013-2014
oaire.awardTitleBioMaTE - A novel bio-manufacturing system to produce bioactive scaffolds for tissue engineering
oaire.awardTitleSkeletal muscle regeneration through the application of cellular therapies and biomaterials - Translation to the veterinary practice alterado para: “Cell-based Therapies in Regenerative Medicine – The therapeuthic potential of Umbilical Cord and Dental Pulp derived Stem / Stromal Cells”
oaire.awardTitleCombined use of olfactory mucosa mesenchymal stem cells and biomaterials in regenerative therapies after peripheral nerve injury
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0211%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FEME%2FUI0285%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMS-SIS%2F7032%2F2014/PT
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oaire.citation.titleInternational Journal of Cell Biologypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
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person.familyNameAlvites
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person.familyNameMaurício
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person.givenNameMariana Esteves
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person.givenNameSílvia Marlene
person.givenNameAlexandra
person.givenNameBeatriz
person.givenNameCláudia
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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