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Solid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applications

2017Journal article Restricted access
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dc.contributor.authorNunes, Sara
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorCampos, Débora
dc.contributor.authorSarmento, Bruno
dc.contributor.authorGomes, Ana Maria
dc.contributor.authorPintado, Manuela
dc.contributor.authorReis, Flávio
dc.date.accessioned2017-10-17T13:53:49Z
dc.date.available2017-10-17T13:53:49Z
dc.date.issued2017
dc.description.abstractDrug delivery systems, accompanied by nanoparticle technology, have recently emerged as prominent solutions to improve the pharmacokinetic properties, namely bioavailability, of therapeutic and nutraceutical agents. Solid lipid nanoparticles (SLNs) have received much attention from researchers due to their potential to protect or improve drug properties. SLNs have been reported to be an alternative system to traditional carriers, such as emulsions, liposomes, and polymeric nanoparticles. Phenolic compounds are widespread in plant-derived foodstuffs and therefore abundant in our diet. Over the last decades, phenolic compounds have received considerable attention due to several health promoting properties, mostly related to their antioxidant activity, which can have important implications for health. However, most of these compounds have been associated with poor bioavailability being poorly absorbed, rapidly metabolized and eliminated, which compromises its biological and pharmacological benefits. This paper provides a systematic review of the use of SLNs as oral delivery systems of phenolic compounds, in order to overcome pharmacokinetic limitations of these compounds and improved nutraceutical potential. In vitro studies, as well as works describing topical and oral treatments will be revisited and discussed. The classification, synthesis, and clinical application of these nanomaterials will be also considered in this review article.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNUNES, Sara; MADUREIRA, Ana Raquel; CAMPOS, Débora A.; SARMENTO, Bruno; GOMES, Ana M. P.; PINTADO, M. E.; REIS, Flávio - Solid lipid nanoparticles as oral delivery systems of phenolic compounds: Overcoming pharmacokinetic limitations for nutraceutical applications. Critical Reviews in Food Science and Nutrition. ISSN 1549-7852. Vol. 57, n.º 9 (2017), p. 1863-1873pt_PT
dc.identifier.doi10.1080/10408398.2015.1031337pt_PT
dc.identifier.eid85014884555
dc.identifier.eissn1549-7852
dc.identifier.issn1040-8398
dc.identifier.pmid26192708
dc.identifier.urihttp://hdl.handle.net/10400.14/23151
dc.identifier.wos000396781200008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francis
dc.relationFCOMP-01-0124-FEDER-028417pt_PT
dc.relationPOCI-01-0145-FEDER-007440pt_PT
dc.relationCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectPharmacokineticspt_PT
dc.subjectOral absorptionpt_PT
dc.subjectBioavailabilitypt_PT
dc.subjectNutraceutical potentialpt_PT
dc.titleSolid lipid nanoparticles as oral delivery systems of phenolic compounds: overcoming pharmacokinetic limitations for nutraceutical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCrosstalk between gut microbiota and metabolic dysregulation in prediabetes – Impact of nutraceutical and therapeutic approaches
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
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oaire.citation.endPage1873
oaire.citation.issue9
oaire.citation.startPage1863
oaire.citation.titleCritical Reviews in Food Science and Nutritionpt_PT
oaire.citation.volume57
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person.familyNameNunes
person.familyNameMadureira
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person.familyNameGomes
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person.familyNameReis
person.givenNameSara Raquel
person.givenNameRaquel
person.givenNameDébora
person.givenNameBruno
person.givenNameAna Maria
person.givenNameMaria Manuela
person.givenNameFlávio
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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