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Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol

2021-11-18Artigo científico Acesso aberto
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dc.contributor.authorPeñalvo, José L.
dc.contributor.authorMertens, Elly
dc.contributor.authorAdemović, Enisa
dc.contributor.authorAkgun, Seval
dc.contributor.authorBaltazar, Ana Lúcia
dc.contributor.authorBuonfrate, Dora
dc.contributor.authorČoklo, Miran
dc.contributor.authorDevleesschauwer, Brecht
dc.contributor.authorValencia, Paula Andrea Diaz
dc.contributor.authorFernandes, João C.
dc.contributor.authorGómez, Enrique Javier
dc.contributor.authorHynds, Paul
dc.contributor.authorKabir, Zubair
dc.contributor.authorKlein, Jörn
dc.contributor.authorKostoulas, Polychronis
dc.contributor.authorJiménez, Lucía Llanos
dc.contributor.authorLotrean, Lucia Maria
dc.contributor.authorMajdan, Marek
dc.contributor.authorMenasalvas, Ernestina
dc.contributor.authorNguewa, Paul
dc.contributor.authorOh, In-Hwan
dc.contributor.authorO'Sullivan, Georgie
dc.contributor.authorPereira, David M.
dc.contributor.authorOrtiz, Miguel Reina
dc.contributor.authorRiva, Silvia
dc.contributor.authorSoriano, Gloria
dc.contributor.authorSoriano, Joan B.
dc.contributor.authorSpilki, Fernando
dc.contributor.authorTamang, Mary Elizabeth
dc.contributor.authorTrofor, Antigona Carmen
dc.contributor.authorVaillant, Michel
dc.contributor.authorIerssel, Sabrina Van
dc.contributor.authorVuković, Jakov
dc.contributor.authorCastellano, José M.
dc.date.accessioned2021-12-08T17:16:36Z
dc.date.available2021-12-08T17:16:36Z
dc.date.issued2021-11-18
dc.description.abstractIntroduction unCoVer - Unravelling data for rapid evidence-based response to COVID-19 - is a Horizon 2020-funded network of 29 partners from 18 countries capable of collecting and using real-world data (RWD) derived from the response and provision of care to patients with COVID-19 by health systems across Europe and elsewhere. unCoVer aims to exploit the full potential of this information to rapidly address clinical and epidemiological research questions arising from the evolving pandemic. Methods and analysis From the onset of the COVID-19 pandemic, partners are gathering RWD from electronic health records currently including information from over 22 000 hospitalised patients with COVID-19, and national surveillance and screening data, and registries with over 1 900 000 COVID-19 cases across Europe, with continuous updates. These heterogeneous datasets will be described, harmonised and integrated into a multi-user data repository operated through Opal-DataSHIELD, an interoperable open-source server application. Federated data analyses, without sharing or disclosing any individual-level data, will be performed with the objective to reveal patients' baseline characteristics, biomarkers, determinants of COVID-19 prognosis, safety and effectiveness of treatments, and potential strategies against COVID-19, as well as epidemiological patterns. These analyses will complement evidence from efficacy/safety clinical trials, where vulnerable, more complex/heterogeneous populations and those most at risk of severe COVID-19 are often excluded. Ethics and dissemination After strict ethical considerations, databases will be available through a federated data analysis platform that allows processing of available COVID-19 RWD without disclosing identification information to analysts and limiting output to data aggregates. Dissemination of unCoVer's activities will be related to the access and use of dissimilar RWD, as well as the results generated by the pooled analyses. Dissemination will include training and educational activities, scientific publications and conference communications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1136/bmjopen-2021-055630pt_PT
dc.identifier.eid85120371425
dc.identifier.issn2044-6055
dc.identifier.pmcPMC8602928
dc.identifier.pmid34794999
dc.identifier.urihttp://hdl.handle.net/10400.14/36141
dc.identifier.wos000720985600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectStatistics & research methodspt_PT
dc.subjectPublic healthpt_PT
dc.titleUnravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.titleBMJ Openpt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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