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Effect of γ-aminobutyric acid (GABA) on the metabolome of two strains of Lasiodiplodia theobromae isolated from grapevine

2020-08-23Journal article Open access
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dc.contributor.authorSalvatore, Maria Michela
dc.contributor.authorFélix, Carna
dc.contributor.authorLima, Fernanda
dc.contributor.authorFerreira, Vanessa
dc.contributor.authorDuarte, Ana Sofia
dc.contributor.authorSalvatore, Francesco
dc.contributor.authorAlves, Artur
dc.contributor.authorEsteves, Ana Cristina
dc.contributor.authorAndolfi, Anna
dc.date.accessioned2021-03-18T15:25:19Z
dc.date.available2021-03-18T15:25:19Z
dc.date.issued2020-08-23
dc.description.abstractThe effect of γ-aminobutyric acid (GABA) on the metabolome of two strains of Lasiodiplodia theobromae isolated from grapevine that hold a different degree of virulence to the host plant (LA-SOL3 (more virulent), LA-SV1 (less virulent)) was investigated. The culture filtrates and crude extracts from the two strains grown in the presence and absence of 10 mM of GABA were tested for phytotoxicity on tomato plant cuttings and leaves, respectively. Considering the opportunistic nature of this fungus for humans, crude extracts were also tested for cytotoxicity on mammalian cell lines. We found that culture filtrates and crude extracts have a decreased toxicity in the presence of GABA. Metabolomic analysis, conducted on both strains at both growth conditions, revealed the production of several compounds, such as indole-3-carboxylic acid (ICA, which is the main compound produced by L. theobromae), 3-indolecarboxyaldehyde, (3R,4S)-botryodiplodin, (R)-mellein. Finally, data demonstrate that GABA both induces a decrease in the amount of ICA, and a diversification of the metabolites produced by L. theobromae.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules25173833pt_PT
dc.identifier.eid85089923492
dc.identifier.issn1420-3049
dc.identifier.pmcPMC7503889
dc.identifier.pmid32842542
dc.identifier.urihttp://hdl.handle.net/10400.14/32269
dc.identifier.wos000571120500001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGrapevinept_PT
dc.subjectIndole-3-carboxylic acidpt_PT
dc.subjectLasiodiplodia theobromaept_PT
dc.subjectPlant diseasespt_PT
dc.subjectSecondary metabolitespt_PT
dc.titleEffect of γ-aminobutyric acid (GABA) on the metabolome of two strains of Lasiodiplodia theobromae isolated from grapevinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt_PT
oaire.citation.titleMolecules (Basel, Switzerland)pt_PT
oaire.citation.volume25pt_PT
person.familyNameSalvatore
person.familyNameFélix
person.familyNameDuarte
person.familyNameAlves
person.familyNameEsteves
person.familyNameANDOLFI
person.givenNameMaria Michela
person.givenNameCarina
person.givenNameAna Sofia
person.givenNameArtur
person.givenNameAna Cristina
person.givenNameAnna
person.identifier295556
person.identifier84187
person.identifier82868
person.identifier724424
person.identifier.ciencia-id2015-2A43-2055
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person.identifier.ciencia-idE713-AE57-5B13
person.identifier.orcid0000-0001-8318-3065
person.identifier.orcid0000-0002-9813-9400
person.identifier.orcid0000-0001-6849-6004
person.identifier.orcid0000-0003-0117-2958
person.identifier.orcid0000-0003-2239-2976
person.identifier.orcid0000-0001-8949-3654
person.identifier.ridA-5212-2009
person.identifier.ridC-3645-2008
person.identifier.ridB-2939-2008
person.identifier.scopus-author-id57200243531
person.identifier.scopus-author-id57188979120
person.identifier.scopus-author-id56817825800
person.identifier.scopus-author-id7103319531
person.identifier.scopus-author-id56379803400
person.identifier.scopus-author-id6603539481
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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