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Biodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F11

2014Journal article Restricted access
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dc.contributor.authorAmorim, Catarina L.
dc.contributor.authorMoreira, Irina S.
dc.contributor.authorMaia, Alexandra S.
dc.contributor.authorTiritan, Maria E.
dc.contributor.authorCastro, Paula M. L.
dc.date.accessioned2014-05-08T14:29:44Z
dc.date.available2014-05-08T14:29:44Z
dc.date.issued2014
dc.description.abstractFluoroquinolone (FQ) antibiotics are extensively used both in human and veterinary medicine, and their accumulation in the environment is causing an increasing concern. In this study, the biodegradation of the three most worldwide used FQs, namely ofloxacin, norfloxacin, and ciprofloxacin, by the fluoroorganic-degrading strain Labrys portucalensis F11 was assessed. Degradation occurred when the FQs were supplied individually or as mixture in the culture medium, in the presence of an easily degradable carbon source. Consumption of individual FQs was achieved at different extents depending on its initial concentration, ranging from 0.8 to 30 μM. For the lowest concentration, total uptake of each FQ was observed but stoichiometric fluoride release was not achieved. Intermediate compounds were detected and identified by LC-MS/MS with a quadrupole time of flight detector analyzer. Biotransformation of FQs by L. portucalensis mainly occurred through a cleavage of the piperazine ring and displacement of the fluorine substituent allowing the formation of intermediates with less antibacterial potency. FQ-degrading microorganisms could be useful for application in bioaugmentation processes towards more efficient removal of contaminants in wastewater treatment plants.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationAMORIM, Catarina L... [et al.] - Biodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F11. Applied Microbiology and Biotechnology. ISSN 1432-0614. Vol. 98, n.º 7 (2014), p. 3181-3190por
dc.identifier.doi10.1007/s00253-013-5333-8
dc.identifier.issn0175-7598
dc.identifier.urihttp://hdl.handle.net/10400.14/14327
dc.identifier.wosWOS:000334167900031
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relationCEQUIMED-Pest-OE/SAU/UI4040/2011
dc.relationMICROBIAL DEGRADATION OF FLUORINATED COMPOUNDS - STUDIES ON BIODEGRADATION MECHANISMS AND BIOTREATMENT SYSTEMS
dc.relationFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectFluoroquinolonespor
dc.subjectLabrys portucalensis F11por
dc.subjectBiodegradationpor
dc.subjectMetabolitespor
dc.titleBiodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F11por
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMICROBIAL DEGRADATION OF FLUORINATED COMPOUNDS - STUDIES ON BIODEGRADATION MECHANISMS AND BIOTREATMENT SYSTEMS
oaire.awardTitleFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F47109%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F87251%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86939%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEBB-EBI%2F111699%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage3190
oaire.citation.issue7
oaire.citation.startPage3181
oaire.citation.titleApplied Microbiology and Biotechnology
oaire.citation.volume98
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAmorim
person.familyNameMoreira
person.familyNameMaia
person.familyNameTiritan
person.familyNameCastro
person.givenNameCatarina L.
person.givenNameIrina Susana Sousa
person.givenNameAlexandra S.
person.givenNameMaria Elizabeth
person.givenNamePaula
person.identifier1394766
person.identifierK-5841-2014
person.identifier1310409
person.identifier2013444
person.identifier.ciencia-id791E-5D42-9B68
person.identifier.ciencia-id161E-A350-7FDE
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person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.orcid0000-0002-6756-552X
person.identifier.orcid0000-0001-6516-0994
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0003-3320-730X
person.identifier.orcid0000-0001-8841-6606
person.identifier.ridK-6091-2014
person.identifier.ridK-5841-2014
person.identifier.ridK-9492-2014
person.identifier.ridM-8241-2013
person.identifier.scopus-author-id36896692500
person.identifier.scopus-author-id36798094100
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id6602890981
person.identifier.scopus-author-id7102781782
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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