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Glyphosate in portuguese adults – a pilot study

2020Journal article Restricted access
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dc.contributor.authorNova, Paulo
dc.contributor.authorCalheiros, Cristina S.C.
dc.contributor.authorSilva, Margarida
dc.date.accessioned2021-01-11T12:25:19Z
dc.date.available2021-01-11T12:25:19Z
dc.date.issued2020
dc.description.abstractBackground: Glyphosate is a broad-spectrum biocide and the active ingredient in the most widely used herbicides worldwide. Since 2015, when the International Agency for Research on Cancer classified it as a Class 2A carcinogen, global interest in this chemical spiked particularly as regards exposure of the general population. Objective: An exploratory glyphosate exposure assessment was conducted among Portuguese adults. Methods: Self-selected participants provided first morning urine which was tested for glyphosate and its metabolite aminomethylphosphonic acid (AMPA) at two distinct periods of time, by two different laboratories using gas chromatography with tandem mass spectrometry (GC-MS-MS) and high performance liquid chromatography linked to triple quadrupole mass spectrometry (HPLC-MS/MS), respectively. Results: In the first round of testing 28% and 50% presented detectable levels of glyphosate and AMPA respectively, with median values of 0.25 and 0.16 μg/L. Systematically available internal dose values were 8.20E- 06 mg/Kg (glyphosate) and 5.04-05 mg/Kg (AMPA). In the second round 73% and 97% presented detectable levels of glyphosate and AMPA respectively with median values of 0.13 and 0.10 μg/L. Systematically available internal dose values were 4.00E-06 mg/Kg (glyphosate) and 3.00E-06 mg/Kg (AMPA). Conclusions: Glyphosate exposure was detected among Portuguese adults, with percentages of glyphosate and AMPA contaminated urine in both rounds of testing and above values from previous studies in other European countries. Systematically available internal doses values were below EFSA’s risk assessment values (ADI or AOEL), and as such, the concentration values measured in this study are not per se a human health problem. Even though there were study limitations, it is the first assessment in Portugal and contributes to the overall knowledge map of glyphosate exposure in Europe.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNova, P., Calheiros, C.S.C., Silva, M. (2020). Glyphosate in portuguese adults – a pilot study. Environmental Toxicology and Pharmacology, 80:103462pt_PT
dc.identifier.doi10.1016/j.etap.2020.103462pt_PT
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/10400.14/31615
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.subjectGlyphosatept_PT
dc.subjectAMPApt_PT
dc.subjectPesticidespt_PT
dc.subjectUrine analysispt_PT
dc.subjectEnvironmental exposurept_PT
dc.subjectHuman biomonitoringpt_PT
dc.titleGlyphosate in portuguese adults – a pilot studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.citation.titleEnvironmental Toxicology and Pharmacologypt_PT
oaire.citation.volume80pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNova
person.familyNameCalheiros
person.familyNameSilva
person.givenNamePaulo
person.givenNameCristina
person.givenNameMargarida
person.identifier.ciencia-id5D16-83EB-7725
person.identifier.ciencia-id5D10-BCF9-05F6
person.identifier.orcid0000-0002-6723-4974
person.identifier.orcid0000-0003-3159-3497
person.identifier.orcid0000-0001-8858-2516
person.identifier.ridA-1151-2011
person.identifier.scopus-author-id57204759788
person.identifier.scopus-author-id10142144500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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