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Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

2020Journal article Restricted access
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dc.contributor.authorCunha, Carla S.
dc.contributor.authorCastro, Pedro J.
dc.contributor.authorSousa, Sérgio C.
dc.contributor.authorPullar, Robert C.
dc.contributor.authorTobaldi, David M.
dc.contributor.authorPiccirillo, Clara
dc.contributor.authorPintado, Maria M.
dc.date.accessioned2020-06-15T08:38:44Z
dc.date.available2020-06-15T08:38:44Z
dc.date.issued2020
dc.description.abstractChitosan is a natural polysaccharide widely used in biomedicine, for instance for wound dressing. Hydroxyapatite is a very bioactive calcium phosphate which, if modified with an appropriate element (iron Fe), can also have UV-absorbing properties. In this work, we report the study of films of chitosan incorporated with iron-modified hydroxyapatite of natural origin (from cod fish bones); this combination led to an innovative chitosan-based material with excellent and advanced functional properties. The films showed very high UV absorption (Ultraviolet Protection Factor (UPF) value higher than 50). This is the first time that a chitosan-based material has shown such high UV protection properties. The films also showed to be non-cytotoxic, and possessed antimicrobial activity towards both Gram-positive and negative strains. Their mechanical properties, optimised with an experimental design approach, confirmed their potential use as multifunctional wound dressing, capable of reducing bacterial infections and, at the same time, protecting from UV light.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCunha, C. S., Castro, P. J., Sousa, S. C., Pullar, R. C., Tobaldi, D. M., Piccirillo, C., & Pintado, M. M. (2020). Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings. International Journal of Biological Macromolecules, 159, 1177-1185pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2020.05.077pt_PT
dc.identifier.eid85086092626
dc.identifier.issn0141-8130
dc.identifier.pmid32416293
dc.identifier.urihttp://hdl.handle.net/10400.14/30711
dc.identifier.wos000564257100008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNORTE-01-0145-FEDER-00012pt_PT
dc.relation2015-0243pt_PT
dc.relationIF/00681/2015pt_PT
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO-Aveiro Institute of Materials
dc.subjectChitosanpt_PT
dc.subjectHydroxyapatitept_PT
dc.subjectWound dressingpt_PT
dc.subjectUV protectionpt_PT
dc.subjectAntibacterialpt_PT
dc.titleFilms of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressingspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50011%2F2020/PT
oaire.citation.endPage1185pt_PT
oaire.citation.startPage1177pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume159pt_PT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePullar
person.familyNamePiccirillo
person.familyNamePintado
person.givenNameRobert
person.givenNameClara
person.givenNameMaria Manuela
person.identifier646900
person.identifier962551
person.identifier456608
person.identifier.ciencia-idD51F-B2C3-B82C
person.identifier.ciencia-id391B-75ED-6983
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-6844-4482
person.identifier.orcid0000-0002-6339-716X
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridN-8206-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id7003296532
person.identifier.scopus-author-id7004621626
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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