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Influence of reduced cortical bone compression by implant macrogeometry on peri-implant bone healing: an In Vitro and In Vivo experimental study

2026-05-01Artigo de investigação Acesso aberto
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dc.contributor.authorGehrke, Sergio Alexandre
dc.contributor.authorJunior, Jaime Aramburú
dc.contributor.authorTreichel, Tiago Luis Eilers
dc.contributor.authorScarano, Antonio
dc.contributor.authorMello, Bruno Freitas
dc.contributor.authorFormiga, Márcio de Carvalho
dc.contributor.authorTari, Sergio Rexhep
dc.contributor.authorCoura, Gustavo
dc.contributor.authorFernandes, Gustavo Vicentis Oliveira
dc.date.accessioned2026-06-05T16:19:58Z
dc.date.available2026-06-05T16:19:58Z
dc.date.issued2026-05-01
dc.description.abstractBackground: Primary stability and long-term osseointegration depend on bone healing surrounding dental implants. Implant macrogeometry is crucial for controlling insertion torque and the biological reaction of peri-implant bone. This study assessed the impact of an implant design meant to lessen cortical bone compression on early bone healing. Methods: Forty titanium prototype implants (3 × 6 mm) were equally divided into Control (standard macrogeometry) and Test (macrogeometry with healing chambers) groups. Initial insertion torque was measured in vitro using synthetic bone blocks. Subsequently, an in vivo rabbit tibia model was used (n = 10 implants per group) to assess early healing. At 21 days, histological sections were analyzed for bone-to-implant contact (BIC%) at three cervical positions (C1, C2, and C3). Additionally, digital radiographs of the cervical region were evaluated using RGB color mapping, where distinct color channels quantified varying degrees of bone density. Results: The in vitro insertion torque for the Control group was significantly greater than the Test group (8.01 vs. 5.70 Ncm). The in vivo histomorphometric analysis indicated improved integration for the Test design, showing substantially higher BIC% at the C2 (59.30% vs. 40.30%) and C3 (42.10% vs. 17.90%) positions. Furthermore, radiographic RGB analysis revealed that the Test group possessed a higher blue channel contribution, indicating greater mineralized tissue density. Conclusions: These results imply that modifying implant macrogeometry to lower insertion torque and minimize cortical bone compression favorably enhances early cervical bone healing and osseointegration.eng
dc.identifier.doi10.3390/jfb17050217
dc.identifier.eid105040029148
dc.identifier.othera2496c8c-6d70-4b22-baaf-e648a836d1fe
dc.identifier.pmid42188383
dc.identifier.urihttp://hdl.handle.net/10400.14/57982
dc.identifier.wos001774716800001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBone healingeng
dc.subjectBone-to-implant contacteng
dc.subjectCortical bone compressioneng
dc.subjectDental implantseng
dc.subjectHealing chamberseng
dc.subjectInsertion torqueeng
dc.subjectOsseointegrationeng
dc.subjectRabbit modeleng
dc.titleInfluence of reduced cortical bone compression by implant macrogeometry on peri-implant bone healing: an In Vitro and In Vivo experimental study
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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