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High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites

2020Journal article Restricted access
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dc.contributor.authorVeiga, Anabela
dc.contributor.authorCastro, Filipa
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorRocha, Fernando
dc.date.accessioned2020-12-11T18:20:39Z
dc.date.available2020-12-11T18:20:39Z
dc.date.issued2020
dc.description.abstractBACKGROUND: Sericin (SS) induces nucleation of bone-like hydroxyapatite (HAp) when used as an organic matrix. HAp/SS nanocomposites have been conventionally synthesized through precipitation in stirred tank reactors (STs). Despite its simplicity, this process is time consuming and presents difficulties in scale-up. In our study, HAp/SS nanocomposites were successfully synthesized in a ST and in a meso-oscillatory flow reactor (meso-OFR), to compare the efficiency of both reactors and to study HAp mineralization using SS as a template. RESULTS: The production of stable HAp, indicated by pH stabilization, was achieved after 180 min in the ST and after 30 min in the meso-OFR. X-ray diffraction and Fourier transform infrared analyses showed that the particles obtained in both reactors are HAp/SS nanocomposites with low crystallinity. Scanning electron microscopy evidenced the formation of rod- and plateshaped nanoparticles and revealed that the presence of SS led to the production of larger particles. The latter observation was confirmed by laser diffraction. Additionally, increasing SS concentration resulted in the formation of more plate-like particles. CONCLUSIONS: Precipitation is more efficient in the meso-OFR, HAp/SS being obtained four times faster. The presence and concentration of SS led to differences in the size and morphology of the synthesized particles, suggesting a critical role of SS in the mineralization process. This work reports a new approach for the manufacture of high-added-value nanocomposites with similar characteristics to biological bone and the results of a study of the influence of SS as an organic component in HAp nucleation. Further, the use of this protein and technology leads to significant waste minimization.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVeiga, A., Castro, F., Oliveira, A.L., Rocha, R. (2020). High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites. Journal Of Chemical Technology And Biotechnology, 96(1), 241-248pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.14/31460
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociety of Chemical Industrypt_PT
dc.relationPTDC/QEQ‐PRS/3787/2014pt_PT
dc.relationPOCI‐01‐0145‐FEDER‐0168pt_PT
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationCentre for Biotechnology and Fine Chemistry
dc.subjectHydroxyapatite/silk sericin nanocompositespt_PT
dc.subjectMeso-oscillatory flow reactorpt_PT
dc.subjectMineralizationpt_PT
dc.subjectProductionpt_PT
dc.subjectSilk byproductpt_PT
dc.titleHigh efficient strategy for the production of hydroxyapatite/silk sericin nanocompositespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FEQU%2F00511%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.endPage248pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage241pt_PT
oaire.citation.titleJournal Of Chemical Technology And Biotechnologypt_PT
oaire.citation.volume96pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes Castro Freitas
person.familyNameOliveira
person.familyNameRocha
person.givenNameFilipa Juliana
person.givenNameAna
person.givenNameFernando
person.identifier1415634
person.identifier.ciencia-idF11F-1863-D018
person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-id9415-187C-AAE3
person.identifier.orcid0000-0001-7447-4063
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0002-2778-8374
person.identifier.ridJ-3404-2013
person.identifier.ridD-4324-2014
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id8864866800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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