Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination

Kunicki, Carolina; Moioli, Renan C.; Pais-Vieira, Miguel; Peres, André Salles Cunha; Morya, Edgard; Nicolelis, Miguel A. L.

Publication

Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination

2019Journal article

dc.contributor.author	Kunicki, Carolina
dc.contributor.author	Moioli, Renan C.
dc.contributor.author	Pais-Vieira, Miguel
dc.contributor.author	Peres, André Salles Cunha
dc.contributor.author	Morya, Edgard
dc.contributor.author	Nicolelis, Miguel A. L.
dc.date.accessioned	2019-04-12T11:38:46Z
dc.date.available	2019-04-12T11:38:46Z
dc.date.issued	2019
dc.description.abstract	Processing of tactile sensory information in rodents is critically dependent on the communication between the primary somatosensory cortex (S1) and higher-order integrative cortical areas. Here, we have simultaneously characterized single-unit activity and local field potential (LFP) dynamics in the S1, primary visual cortex (V1), anterior cingulate cortex (ACC), posterior parietal cortex (PPC), while freely moving rats performed an active tactile discrimination task. Simultaneous single unit recordings from all these cortical regions revealed statistically significant neuronal firing rate modulations during all task phases (anticipatory, discrimination, response, and reward). Meanwhile, phase analysis of pairwise LFP recordings revealed the occurrence of long-range synchronization across the sampled fronto-parieto-occipital cortical areas during tactile sampling. Causal analysis of the same pairwise recorded LFPs demonstrated the occurrence of complex dynamic interactions between cortical areas throughout the fronto-parietal-occipitl loop. These interactions changed significantly between cortical regions as a function of frequencies (i.e. beta, theta and gamma) and according to the different phases of the behavioral task. Overall, these findings indicate that active tactile discrimination by rats is characterized by much more widespread and dynamic complex interactions within the fronto-parieto-occipital cortex than previously anticipated.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Kunicki, C., C. Moioli, R., Pais-Vieira, M., Salles Cunha Peres, A., Morya, E., & A. L. Nicolelis, M. (2019). Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-41516-3	pt_PT
dc.identifier.doi	10.1038/s41598-019-41516-3	pt_PT
dc.identifier.eid	85063442684
dc.identifier.issn	2045-2322
dc.identifier.pmc	PMC6434051
dc.identifier.pmid	30911025
dc.identifier.uri	http://hdl.handle.net/10400.14/27395
dc.identifier.wos	000462149800060
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Nature Publishing Group	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.title	Frequency-specific coupling in fronto-parieto-occipital cortical circuits underlie active tactile discrimination	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.title	Scientific Reports	pt_PT
oaire.citation.volume	9
person.familyName	Moioli
person.familyName	Pais-Vieira
person.familyName	Morya
person.givenName	Renan
person.givenName	Miguel
person.givenName	Edgard
person.identifier.ciencia-id	0B17-4D35-03BF
person.identifier.orcid	0000-0001-6036-8358
person.identifier.orcid	0000-0002-1398-9060
person.identifier.orcid	0000-0003-0954-5317
person.identifier.scopus-author-id	15842137800
person.identifier.scopus-author-id	6506185708
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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