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Targeting human skin health: bioactive evaluation of acorn shell and red grape pomace extracts against pathogens and skin cells

2025-08-11Artigo de investigação Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorOliveira, Cláudia S.
dc.contributor.authorMelo, Adma
dc.contributor.authorRibeiro, Tania
dc.contributor.authorPintado, Manuela
dc.contributor.authorTavaria, Freni K.
dc.date.accessioned2025-09-08T08:20:50Z
dc.date.available2025-09-08T08:20:50Z
dc.date.issued2025-08-11
dc.description.abstractThe agricultural and food sectors generate substantial amounts of by-products that are usually discarded as waste. However, agri-food by-products, rich in many bioactive compounds (BCs), can find several applications while promoting sustainability. Acorn shell (AS) and red grape pomace (RGP) stand out as valuable sources of BCs. To be used in human skin, the biological properties of these by-products need to be investigated. Therefore, this study explored the chemical composition of AS and RGP extracts and evaluated their concentration-dependent effects on key pathogenic (Staphylococcus aureus) and non-pathogenic (Staphylococcus epidermidis) bacteria of the skin microbiota, as well as on resident skin cells (keratinocytes) and skin cancer cells. The AS extract, rich in phenolic acids and gallotannins, and RGP extract, abundant in flavonoids, demonstrated significant antimicrobial activity by inhibiting bacterial growth and biofilm formation (peng
dc.identifier.citationOliveira, C. S., Melo, A., Ribeiro, T., & Pintado, M. et al. (in press). Targeting human skin health: bioactive evaluation of acorn shell and red grape pomace extracts against pathogens and skin cells. Fitoterapia, 186, Article 106798. https://doi.org/10.1016/j.fitote.2025.106798
dc.identifier.doi10.1016/j.fitote.2025.106798
dc.identifier.eid105013144881
dc.identifier.issn0367-326X
dc.identifier.other0dc45157-c29f-4bf5-93e8-ec999ff0bdff
dc.identifier.urihttp://hdl.handle.net/10400.14/54701
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcorn shell
dc.subjectAgri-food by-products
dc.subjectBioactive compounds
dc.subjectBioactive extracts
dc.subjectRed grape pomace
dc.subjectSkin applications
dc.titleTargeting human skin health: bioactive evaluation of acorn shell and red grape pomace extracts against pathogens and skin cellseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleFitoterapia
oaire.citation.volume186
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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