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Browsing by Issue Date, starting with "2025-08-11"

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  • Indústrias criativas e novas tecnologias, transformações e desafios
    Publication . Cortez, Maria Raquel; Teixeira, Luís
    Este artigo pretende contribuir para o debate sobre a utilização da Inteligência Artificial e as suas implicações sociais no desenvolvimento de setores como as indústrias do setor criativo. Assim, a ligação entre inteligência artificial e indústrias criativas levanta algumas questões. Que desafios trazem estas ferramentas de IA para os profissionais criativos? Elas colocam postos de trabalho em risco? A expressão artística, como a entendemos, deixará de existir? Que questões éticas levanta a utilização da IA? Devemos temê-la ou aceitá-la abertamente?
    2025-08-11Conference proceedings Open access Show more
  • Residências VERTIGO STARTS: o papel da arte na inovação industrial
    Publication . Teixeira, Luís Miguel; Oliveira, Carla Esmeraldo
    Este artigo tem como principal objetivo discutir o papel da arte, particularmente através das VERTIGO-STARTS Residencies, na promoção da inovação em contextos industriais. A crescente convergência entre arte, ciência e tecnologia está a transformar a forma como a inovação é concebida e implementada. Neste cenário, as residências artísticas do programa VERTIGO-STARTS demonstram o poder da integração de artistas em ambientes industriais e tecnológicos, criando um terreno fértil para a geração de novas ideias e soluções criativas.
    2025-08-11Conference proceedings Open access Show more
  • Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety
    Publication . Almeida, António Rocha de; Lima, Maria Rita; Gomes, Daniel A.; Almeida, Manuel de Sousa; Fernandes, Renato; Oliveira, Eduardo Infante; Gonçalves, Pedro Araújo; Teles, Rui Campante; Patrício, Lino
    Background and aims: Severe aortic stenosis (AS) was traditionally managed with surgical aortic valve replacement (SAVR). Transcatheter aortic valve implantation (TAVI) emerged as a less invasive alternative, initially for high-risk patients. This meta-analysis evaluates the outcomes of TAVI in younger, low-risk patients, in whom SAVR is currently the gold standard. Methods: Following PRISMA guidelines, we systematically searched randomized controlled trials (RCTs) comparing TAVI with SAVR in younger (mean age <75 years) low-risk patients (STS score <4%) with severe AS. The primary endpoint was a composite of death or disabling stroke. Secondary endpoints included all-cause mortality, disabling stroke, atrial fibrillation (AF), permanent pacemaker implantation (PPI), bleeding, functional class (NYHA), and quality-of-life (KCCQ score) improvements. Results: Four RCTs were included with 4,252 patients (2,125 TAVI and 2,127 SAVR). At a mean follow-up of 16 ± 5 months, TAVI showed a non-significant reduction in the composite of death or disabling stroke [2.8% vs. 5.1% risk ratio (RR) 0.98, 95% confidence interval (CI) (0.96–1.00), p = 0.11] and all-cause mortality [2.1% vs. 3.7%, RR 0.99, 95% CI (0.97–1.00), p = 0.15]. The incidence of disabling stroke was significantly lower in TAVI [0.9 vs. 2.1 RR 0.99, 95% CI (0.98–1.00), p < 0.01]. Hospital readmission [7.1% vs. 9.5% RR 0.97, 95% CI (0.96–0.99), p < 0.01] and bleeding rates [4.7% vs. 16%, RR 0.87, 95% CI (0.82–0.93), p < 0.01] were significantly lower in the TAVI group. Conversely, TAVI had a higher PPI rate [14% vs. 6%, RR 1.08, 95% CI (1.02–1.14), p < 0.01]. Faster symptomatic and quality-of-life improvements were sustained in the TAVI group. Conclusions: TAVI is a viable option for younger low-risk patients with severe AS, being non-inferior to SAVR in short-term outcomes. The benefits of TAVI include a lower risk of disabling stroke, hospital readmission, and bleeding, as well as quicker improvements in symptoms and quality of life. However, higher PPI rates require careful patient selection. The results support a tailored approach to TAVI in younger patients, with ongoing evaluation of long-term outcomes. Systematic Review Registration: https: www.crd.york.ac.uk/PROSPERO/view/CRD42024559473, PROSPERO (CRD42024559473).
    2025-08-11Review article Open access Show more
  • Targeting human skin health: bioactive evaluation of acorn shell and red grape pomace extracts against pathogens and skin cells
    Publication . Oliveira, Cláudia S.; Melo, Adma; Ribeiro, Tania; Pintado, Manuela; Tavaria, Freni K.
    The agricultural and food sectors generate substantial amounts of by-products that are usually discarded as waste. However, agri-food by-products, rich in many bioactive compounds (BCs), can find several applications while promoting sustainability. Acorn shell (AS) and red grape pomace (RGP) stand out as valuable sources of BCs. To be used in human skin, the biological properties of these by-products need to be investigated. Therefore, this study explored the chemical composition of AS and RGP extracts and evaluated their concentration-dependent effects on key pathogenic (Staphylococcus aureus) and non-pathogenic (Staphylococcus epidermidis) bacteria of the skin microbiota, as well as on resident skin cells (keratinocytes) and skin cancer cells. The AS extract, rich in phenolic acids and gallotannins, and RGP extract, abundant in flavonoids, demonstrated significant antimicrobial activity by inhibiting bacterial growth and biofilm formation (p
    2025-08-11Research article Open access Show more