Insights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological study

Alves, Maria José; Ferreira, Isabel C. F. R.; Barreira, João C. M.; Pimentel, Helena; Pintado, Manuela

Publication

Insights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological study

2014-10Journal article

dc.contributor.author	Alves, Maria José
dc.contributor.author	Ferreira, Isabel C. F. R.
dc.contributor.author	Barreira, João C. M.
dc.contributor.author	Pimentel, Helena
dc.contributor.author	Pintado, Manuela
dc.date.accessioned	2023-03-09T12:24:08Z
dc.date.available	2023-03-09T12:24:08Z
dc.date.issued	2014-10
dc.description.abstract	Introduction: The emergence and propagation of multi-resistant bacteria in the hospital environment have become serious epidemiological and therapeutic problems. It is essential to update data regarding the susceptibility to the most commonly used antibiotics in each hospital, allowing obtaining specific resistance patterns to define the antibiotic therapy. Objectives: This study aims to establish a profile of susceptibility vs. resistance for different microorganisms isolated during 3 years (2009-2011) using 3300 clinical isolates of different biological samples obtained from different hospital units belonging to Centro Hospitalar de Trás-os-Montes e Alto Douro (CHTMAD). Methods: Identification and susceptibility tests were done using microdilution plate method and results were submitted to principal component analysis (PCA). Results: Methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecium and coagulase negative Staphylococcus (CNS) seem to be the most concerning Gram positive microorganisms. For Gram negative species, despite the high resistance presented by Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBL) to b-lactamic antibiotics, imipenem is still a good therapeutic option, as well as fosfomycin (for urinary infection). Stenotrophomonas maltophilia, Pseudomonas aeruginosa MR and Acinetobacter baumannii, are progressively acquiring higher resistance to these antibiotics, mainly to imipenem, cotrimoxazol and even aminoglycosides (tobramycin and gentamycin). Conclusions: Overall, the developed resistance seems to be directly associated with antibiotics use and, therefore, studies centered in multi-resistance to antibiotics are crucial to establish dynamic protocols adequate to specific resistance vs. susceptibility profiles.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.issn	0212-6567
dc.identifier.uri	http://hdl.handle.net/10400.14/40518
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	pt_PT
dc.subject	Multidrug-resistant microorganism	pt_PT
dc.subject	Surveillance	pt_PT
dc.title	Insights on the evolution of bacterial susceptibility exposed to multiple antibiotics: a triennial epidemiological study	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	51	pt_PT
oaire.citation.startPage	51	pt_PT
oaire.citation.title	Atención Primaria	pt_PT
oaire.citation.volume	46	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT