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Exploring the effect of flavonoid-based solutions or formulations as antibiofilm agents in endodontics: a scoping review

2026-06-01Artigo de investigação Acesso aberto
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dc.contributor.authorNunes, Gabriel Pereira
dc.contributor.authorSaint-Etienne, Elise
dc.contributor.authorMello-Moura, Anna Carolina Volpi
dc.contributor.authorDanelon, Marcelle
dc.contributor.authorSterzenbach, Torsten
dc.contributor.authorHannig, Christian
dc.contributor.authorAlves, Renata Toledo
dc.contributor.authorDuque, Cristiane
dc.date.accessioned2026-03-03T09:49:29Z
dc.date.available2026-03-03T09:49:29Z
dc.date.issued2026-06-01
dc.description.abstractObjective This scoping review aimed to map and summarize the evidence on the antimicrobial and antibiofilm efficacy of flavonoid-based solutions or formulations for endodontic applications. Design The review was conducted in accordance with the PRISMA-ScR guidelines. A comprehensive search was performed across databases for articles published up to April 2025. Eligible studies included those evaluating the antimicrobial effects of flavonoids on microorganisms associated with endodontic infections. Relevant data were extracted, and a descriptive synthesis of the findings was carried out. Results The results showed that fifteen studies met the inclusion criteria, demonstrating significant antimicrobial and antibiofilm activity of various flavonoids. Epigallocatechin-3-gallate was the most extensively studied compound, showing dose-dependent activity against E. faecalis, F. nucleatum, A. israelii, S. mutans, and C. albicans, with enhanced efficacy when combined with agents such as fosfomycin or the peptide KR-12-a5. Quercetin also displayed concentration-dependent antibiofilm effects and gene modulation in E. faecalis. Proanthocyanidin showed superior efficacy compared to conventional irrigants, especially at higher concentrations. Rutin, although limited in standalone efficacy, showed promising results when used as a photosensitizer. Other flavonoids such as apigenin, theaflavin, isoquercitrin, ampelopsin, chalcone, and chrysin also demonstrated varying degrees of antimicrobial activity, often similar to or surpassing conventional agents like chlorhexidine and calcium hydroxide in specific models. Conclusions Flavonoids exhibit significant potential as alternative or adjunctive agents for endodontic disinfection, especially in biofilm-related infections. Their efficacy is influenced by compound type, concentration, formulation, and synergistic combinations. Further research, especially clinical trials, is warranted to validate their therapeutic applicability and optimize delivery systems for clinical use in endodontics.eng
dc.identifier.citationNunes, G. P., Saint-Etienne, E., Mello-Moura, A. C. V., Danelon, M., Sterzenbach, T., Hannig, C., Duque, C., & Alves, R. T. (in press). Exploring the effect of flavonoid-based solutions or formulations as antibiofilm agents in endodontics: a scoping review. Archives of Oral Biology, 186, Article 106559. https://doi.org/10.1016/j.archoralbio.2026.106559
dc.identifier.doi10.1016/j.archoralbio.2026.106559
dc.identifier.issn0003-9969
dc.identifier.othere8e51456-3fd6-4eed-a36b-d1258ec6129b
dc.identifier.urihttp://hdl.handle.net/10400.14/57245
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntimicrobial activity
dc.subjectBiofilms
dc.subjectEndodontics
dc.subjectFlavonoids
dc.subjectIntracanal medication
dc.titleExploring the effect of flavonoid-based solutions or formulations as antibiofilm agents in endodontics: a scoping revieweng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleArchives of Oral Biology
oaire.citation.volume186
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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