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A novel biological dermal matrix for skin reconstruction

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Skin and soft tissue defects from trauma, burns, or surgical resection remain a major clinical challenge. Biological dermal substrates support reconstructive surgery by providing a scaffold for neovascularization and wound healing, but accessible alternatives with comparable performance are still needed. We developed a novel dermal substrate from rabbit skin, a sustainable agri-food by-product, preserving a collagen-elastin network and ECM organization similar to human dermis. Its performance was benchmarked against two commercial substitutes, Matriderm® (MedSkin) and NovoSorb® (PolyNovo).

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