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Optimization of high hydrostatic pressure assisted extraction of stinging nettle leaves using response surface methodology experimental design

2020Journal article Restricted access
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dc.contributor.authorMoreira, Sílvia A.
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorSaraiva, Jorge A.
dc.date.accessioned2020-08-07T10:45:06Z
dc.date.available2020-08-07T10:45:06Z
dc.date.issued2020
dc.description.abstractHigh hydrostatic pressure assisted extraction (HPE) is a very promising extraction methodology since it can operate at room temperature and therefore can avoid heat-sensitive compounds changes. Furthermore, it is recognized as a fast technology (only a few minutes) and it is also an already proven environmentally friendly technology. This is the first work to study HPE effect as a new extraction method to obtain improved extracts from stinging nettle, a commonly known weed, traditionally used as folk medicine and with several biological properties proven scientifically. In this work, the HPE process was optimized by an experimental design via response surface methodology using a central composite face-centered design. The effect of pressure level, extraction time, and solvent concentration were evaluated, as also the impact of HPE on total phenolics (TPC), flavonoids, pigments, and antioxidant activity. Results showed that experimental data could be well fitted to second-order polynomial mathematical models, since lack-of-fit values were non-significant and the regression coefficients were above 75%. The optimal conditions for the overall maximization of extraction yield, TPC and antioxidant activity were 200 MPa, 10.2–15.6 min, and 0% ethanol (aqueous extracts), which were tested in a further experiment confirming the predictability of all models (difference by percentage between predicted and experimental optimum were all below 10%. When compared to extraction at atmospheric pressure, HPE allowed increasing the extraction yield about 50.5%; TPC about 84.4%; and antioxidant activity about 77.7%. All the models fitted well the experimental data, being the observed values close to the predicted ones by the model equation.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationMoreira, S. A., Pintado, M. E., Saraiva, J. A. (2020). Optimization of high hydrostatic pressure assisted extraction of stinging nettle leaves using response surface methodology experimental design. Journal of Food Measurement and Characterizationpt_PT
dc.identifier.doi10.1007/s11694-020-00522-0pt_PT
dc.identifier.eid85088814233
dc.identifier.eissn2193-4134
dc.identifier.issn2193-4126
dc.identifier.urihttp://hdl.handle.net/10400.14/30835
dc.identifier.wos000559367700039
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationFRH/BD/110430/2015pt_PT
dc.relationOrganic Chemistry, Natural Products and Food Stuffs
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCentre for Biotechnology and Fine Chemistry
dc.subjectExtraction optimizationpt_PT
dc.subjectResponse surface methodologypt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectHighpressure extractionpt_PT
dc.titleOptimization of high hydrostatic pressure assisted extraction of stinging nettle leaves using response surface methodology experimental designpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOrganic Chemistry, Natural Products and Food Stuffs
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00062%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.titleJournal of Food Measurement and Characterizationpt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMoreira
person.familyNamePintado
person.familyNameSaraiva
person.givenNameSilvia
person.givenNameMaria Manuela
person.givenNameJorge
person.identifier456608
person.identifier.ciencia-idE21A-210C-756F
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-idEC16-41A3-01BD
person.identifier.orcid0000-0003-2339-9790
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0002-5536-6056
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id56493264800
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id35583570500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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