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In situ crosslinked electrospun gelatin nanofibers for skin regeneration

2017Journal article Open access
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dc.contributor.authorDias, J. R.
dc.contributor.authorBaptista-Silva, S.
dc.contributor.authorOliveira, C. M. T. de
dc.contributor.authorSousa, A.
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorBártolo, P. J.
dc.contributor.authorGranja, P. L.
dc.date.accessioned2017-12-18T18:53:22Z
dc.date.available2017-12-18T18:53:22Z
dc.date.issued2017
dc.description.abstractDue to its intrinsic similarity to the extracellular matrix, gelatin electrospun nanofibrous meshes are promising scaffold structures for wound dressings and tissue engineering applications. However, gelatin is water soluble and presents poor mechanical properties, which generally constitute relevant limitations to its applicability. In this work, gelatin was in situ crosslinked with 1,4-butanediol diglycidyl ether (BDDGE) at different concentrations (2, 4 and 6 wt%) and incubation time-points (24, 48 and 72 h) at 37 °C. The physico-chemical and biological properties of BDDGE-crosslinked electrospun gelatin meshes were investigated. Results show that by changing the BDDGE concentration it is possible to produce nanofibers crosslinked in situ with well-defined morphology and modulate fiber size and mechanical properties. Crosslinked gelatin meshes show no toxicity towards fibroblasts, stimulating their adhesion, proliferation and synthesis of new extracellular matrix, thereby indicating the potential of this strategy for skin tissue engineering.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationDias, J. R., Baptista-Silva, S., de Oliveira, C. M. T., Sousa, A., Oliveira, A. L., Bartolo, P. J., & Granja, P. L. (2017). In situ crosslinked electrospun gelatin nanofibers for skin regeneration. European Polymer Journal, 95, 161-173pt_PT
dc.identifier.doi10.1016/j.eurpolymj.2017.08.015pt_PT
dc.identifier.eid85026912199
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/10400.14/23719
dc.identifier.wos000414886300013
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIF/00411/2013pt_PT
dc.relationIn situ skin tissue engineering
dc.relationBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectIn situ crosslinkingpt_PT
dc.subjectElectrospun fiberspt_PT
dc.subjectGelatinpt_PT
dc.subjectBDDGEpt_PT
dc.subjectWound dressingpt_PT
dc.titleIn situ crosslinked electrospun gelatin nanofibers for skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIn situ skin tissue engineering
oaire.awardTitleBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBBB-ECT%2F2145%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04044%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F91104%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F90047%2F2012/PT
oaire.citation.endPage173pt_PT
oaire.citation.startPage161pt_PT
oaire.citation.titleEuropean Polymer Journalpt_PT
oaire.citation.volume95pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameDias
person.familyNameBaptista da Silva
person.familyNameOliveira
person.familyNameSousa
person.familyNameOliveira
person.familyNameGranja
person.givenNameJuliana
person.givenNameSara
person.givenNameCarla
person.givenNameAureliana
person.givenNameAna
person.givenNamePedro
person.identifier633669
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person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-idDB1F-B9B7-E4FD
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0003-1805-144X
person.identifier.orcid0000-0001-8340-2264
person.identifier.orcid0000-0003-2191-8892
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0003-2761-4929
person.identifier.ridV-9083-2017
person.identifier.ridF-8188-2011
person.identifier.ridG-6286-2014
person.identifier.ridJ-3404-2013
person.identifier.ridB-1685-2008
person.identifier.scopus-author-id55493446000
person.identifier.scopus-author-id50060987900
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person.identifier.scopus-author-id35345790700
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id6602391346
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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