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Minimal relative absent words as candidate host-pathogen signatures for innovative diagnosis
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Minimal Relative Absent Words (mRAWs) are the shortest nucleotide sequences occurring in one genome, such as a pathogen, while being absent from another, such as the host, making them potential genomic signatures. Recent work on SARS-CoV-2 showed that shorter mRAWs tend to exhibit higher GC-content than both the human and virus genomes and transcriptomes and identified a persistent mRAW in the Spike gene, a key protein involved in host-cell entry, highlighting the relevance of absent words for pathogen detection.