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Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice

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dc.contributor.authorAraújo, Daline F. S.
dc.contributor.authorGuerra, Gerlane C. B.
dc.contributor.authorPintado, M.
dc.contributor.authorSousa, Yasmim R. F.
dc.contributor.authorAlgieri, Francesca
dc.contributor.authorRodriguez-Nogales, Alba
dc.contributor.authorAraujo, Raimundo F. Jr.
dc.contributor.authorGalvez, Julio
dc.contributor.authorQueiroga, Rita de Cassia R. E.
dc.contributor.authorRodriguez-Cabezas, Maria Elena
dc.date.accessioned2018-11-06T18:20:15Z
dc.date.available2018-11-06T18:20:15Z
dc.date.issued2017
dc.description.abstractThis study evaluated the intestinal anti-inflammatory effects of goat whey in a mouse model of colitis induced by 2,4-dinitrobenzenesulfonic acid that resembles human IBD. At a concentration of 4 g/kg/day, the goat whey improved the symptoms of intestinal inflammation, namely by decreasing the disease activity index, colonic weight/length, and leukocyte infiltration. Moreover, goat whey inhibited NF-kappa B p65 and p38 MAPK signaling pathways and consequently down-regulated the gene expression of various proinflammatory markers such as IL-1 beta, IL-6, IL-17, TNF-alpha, iNOS, MMP-9, ICAM-1. Also, goat whey increased the expression of proteins such as mucins, occludin proteins and cytokine signalling suppressors. The immunomodulatory properties of goat whey were also evaluated in vitro using the murine macrophage cell line Raw 264 and CMT-93 cells derived from mouse rectum carcinomas. The results revealed the ability of goat whey to inhibit the production of NO and reduce IL-6 production in LPS-stimulated cells. In conclusion, goat whey exhibited antiinflammatory effects in the DNBS model of intestinal inflammation, and these observations were confirmed by its immunomodulatory properties in vitro. Together, our results indicate that goat whey could have applications for the treatment of IBD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAraújo, D.F.S., Guerra, G.C.B., Pintado, M.E., Sousa, Y.R.F., Algieri, F., Rodriguez-Nogales, A., … Rodriguez-Cabezas, N.E. (2017). Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice. PLoS ONE, 12(9), e0185382pt_PT
dc.identifier.doi10.1371/journal.pone.0185382pt_PT
dc.identifier.eid85030026848
dc.identifier.issn1932-6203
dc.identifier.pmcPMC5619769
dc.identifier.pmid28957373
dc.identifier.urihttp://hdl.handle.net/10400.14/25998
dc.identifier.wos000411985200052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationCTS 164
dc.relationAGL2015-67995-C3-3-R
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleIntestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePLoS ONEpt_PT
person.familyNamePintado
person.familyNameAraújo Júnior
person.familyNameGalvez
person.familyNamerodriguez-cabezas
person.givenNameMaria Manuela
person.givenNameRaimundo Fernandes
person.givenNameJulio
person.givenNamemaria elena
person.identifier456608
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0003-2349-2354
person.identifier.orcid0000-0001-6876-3782
person.identifier.orcid0000-0001-9085-8147
person.identifier.ridF-5696-2013
person.identifier.ridK-6875-2014
person.identifier.ridL-3086-2014
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id6602880894
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication335ccbbe-9318-472b-96ed-5e75c78188cb
relation.isAuthorOfPublication29e2eb66-4c02-4ac7-b5ae-649a3e9138cd
relation.isAuthorOfPublicatione65aec6f-f7e1-4acf-9428-2ea1722b9090
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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