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In situ enabling approaches for tissue regeneration: current challenges and new developments

dc.contributor.authorDias, Juliana R.
dc.contributor.authorRibeiro, Nilza
dc.contributor.authorBaptista-Silva, Sara
dc.contributor.authorCosta-Pinto, Ana Rita
dc.contributor.authorAlves, Nuno
dc.contributor.authorOliveira, Ana. L.
dc.date.accessioned2020-03-19T15:40:46Z
dc.date.available2020-03-19T15:40:46Z
dc.date.issued2020
dc.description.abstractIn situ tissue regeneration can be defined as the implantation of tissue-specific biomaterials (by itself or in combination with cells and/or biomolecules) at the tissue defect, taking advantage of the surrounding microenvironment as a natural bioreactor. Up to now, the structures used were based on particles or gels. However, with the technological progress, the materials’ manipulation and processing has become possible, mimicking the damaged tissue directly at the defect site. This paper presents a comprehensive review of current and advanced in situ strategies for tissue regeneration. Recent advances to put in practice the in situ regeneration concept have been mainly focused on bioinks and bioprinting techniques rather than the combination of different technologies to make the real in situ regeneration. The limitation of conventional approaches (e.g., stem cell recruitment) and their poor ability to mimic native tissue are discussed. Moreover, the way of advanced strategies such as 3D/4D bioprinting and hybrid approaches may contribute to overcome the limitations of conventional strategies are highlighted. Finally, the future trends and main research challenges of in situ enabling approaches are discussed considering in vitro and in vivo evidence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, J. R., Ribeiro, N., Baptista-Silva, S., Costa-Pinto, A. R., Alves, N., Oliveira, A. L. (2020). In situ enabling approaches for tissue regeneration: current challenges and new developments. Frontiers in Bioengineering and Biotechnology, 8, art. n.º85pt_PT
dc.identifier.doi10.3389/fbioe.2020.00085pt_PT
dc.identifier.eid85080907653
dc.identifier.issn2296-4185
dc.identifier.pmcPMC7039825
dc.identifier.pmid32133354
dc.identifier.urihttp://hdl.handle.net/10400.14/30052
dc.identifier.wos000518921300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationPOCI-01-0145-FEDER-31146pt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationPOCI-01-0247-FEDER-024533pt_PT
dc.relationNew bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIn situ approachespt_PT
dc.subjectTissue regenerationpt_PT
dc.subjectBioprintingpt_PT
dc.subjectIn situ biomaterialspt_PT
dc.subjectComputer/non-computer assisted approachespt_PT
dc.titleIn situ enabling approaches for tissue regeneration: current challenges and new developmentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleNew bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F116024%2F2016/PT
oaire.citation.titleFrontiers in Bioengineering and Biotechnologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1f76a7db-2520-482f-b56b-7e01ea36dd1f
relation.isProjectOfPublicationb5bb5c22-a402-4feb-b275-d41ed654cbd6
relation.isProjectOfPublication5e5b7b8e-8669-4eec-ad52-01bd9695b71a
relation.isProjectOfPublication.latestForDiscoveryb5bb5c22-a402-4feb-b275-d41ed654cbd6

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