Publication
In situ enabling approaches for tissue regeneration: current challenges and new developments
| dc.contributor.author | Dias, Juliana R. | |
| dc.contributor.author | Ribeiro, Nilza | |
| dc.contributor.author | Baptista-Silva, Sara | |
| dc.contributor.author | Costa-Pinto, Ana Rita | |
| dc.contributor.author | Alves, Nuno | |
| dc.contributor.author | Oliveira, Ana. L. | |
| dc.date.accessioned | 2020-03-19T15:40:46Z | |
| dc.date.available | 2020-03-19T15:40:46Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | In situ tissue regeneration can be defined as the implantation of tissue-specific biomaterials (by itself or in combination with cells and/or biomolecules) at the tissue defect, taking advantage of the surrounding microenvironment as a natural bioreactor. Up to now, the structures used were based on particles or gels. However, with the technological progress, the materials’ manipulation and processing has become possible, mimicking the damaged tissue directly at the defect site. This paper presents a comprehensive review of current and advanced in situ strategies for tissue regeneration. Recent advances to put in practice the in situ regeneration concept have been mainly focused on bioinks and bioprinting techniques rather than the combination of different technologies to make the real in situ regeneration. The limitation of conventional approaches (e.g., stem cell recruitment) and their poor ability to mimic native tissue are discussed. Moreover, the way of advanced strategies such as 3D/4D bioprinting and hybrid approaches may contribute to overcome the limitations of conventional strategies are highlighted. Finally, the future trends and main research challenges of in situ enabling approaches are discussed considering in vitro and in vivo evidence. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Dias, J. R., Ribeiro, N., Baptista-Silva, S., Costa-Pinto, A. R., Alves, N., Oliveira, A. L. (2020). In situ enabling approaches for tissue regeneration: current challenges and new developments. Frontiers in Bioengineering and Biotechnology, 8, art. n.º85 | pt_PT |
| dc.identifier.doi | 10.3389/fbioe.2020.00085 | pt_PT |
| dc.identifier.eid | 85080907653 | |
| dc.identifier.issn | 2296-4185 | |
| dc.identifier.pmc | PMC7039825 | |
| dc.identifier.pmid | 32133354 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/30052 | |
| dc.identifier.wos | 000518921300001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Frontiers Media | pt_PT |
| dc.relation | POCI-01-0145-FEDER-31146 | pt_PT |
| dc.relation | Centre for Biotechnology and Fine Chemistry | |
| dc.relation | Centre for Rapid and Sustainable Product Development | |
| dc.relation | POCI-01-0247-FEDER-024533 | pt_PT |
| dc.relation | New bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | In situ approaches | pt_PT |
| dc.subject | Tissue regeneration | pt_PT |
| dc.subject | Bioprinting | pt_PT |
| dc.subject | In situ biomaterials | pt_PT |
| dc.subject | Computer/non-computer assisted approaches | pt_PT |
| dc.title | In situ enabling approaches for tissue regeneration: current challenges and new developments | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Centre for Biotechnology and Fine Chemistry | |
| oaire.awardTitle | Centre for Rapid and Sustainable Product Development | |
| oaire.awardTitle | New bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F116024%2F2016/PT | |
| oaire.citation.title | Frontiers in Bioengineering and Biotechnology | pt_PT |
| oaire.citation.volume | 8 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | POR_NORTE | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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