Repository logo
 
Publication

European guidelines on treatment and supportive measures in chronic neutropenias: a consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence review

2025-04Research article Open access
Simple item page
dc.contributor.authorFioredda, Francesca
dc.contributor.authorSpanoudakis, Michail
dc.contributor.authorSkokowa, Julia
dc.contributor.authorTamary, Hannah
dc.contributor.authorFarruggia, Piero
dc.contributor.authorAlmeida, António
dc.contributor.authorGuardo, Daniela
dc.contributor.authorPalmblad, Jan
dc.contributor.authorHöglund, Petter
dc.contributor.authorTouw, Ivo P.
dc.contributor.authorZeidler, Cornelia
dc.contributor.authorWarren, Alan J.
dc.contributor.authorCsenar, Mario
dc.contributor.authorSkoetz, Nicole
dc.contributor.authorCastagnola, Elio
dc.contributor.authorRicci, Erica
dc.contributor.authorDale, David C.
dc.contributor.authorNewburger, Peter E.
dc.contributor.authorWelte, Karl
dc.contributor.authorPapadaki, Helen A.
dc.contributor.authorDufour, Carlo
dc.date.accessioned2025-07-16T13:26:53Z
dc.date.available2025-07-16T13:26:53Z
dc.date.issued2025-04
dc.description.abstractThe treatment of chronic neutropenias and control of neutropenia-related infections remain challenging topics for pediatric and adult hematologists. This article aims to fill the gap in the treatment of neutropenias and, in combination with the previously published European guidelines on diagnosis of neutropenias, gives complete and comprehensive guidance on the whole management of patients with neutropenia. In terms of methodology, an Evidence-Based Medicine team produced an evidence synthesis of the literature on the treatment of neutropenias. Then, according to the robustness of the evidence, consensus recommendations were elaborated and voted by an expert's panel from the Cooperation in Science and Technology European Network for the Innovative Diagnosis and Treatment of Chronic Neutropenias (https://eunet-innochron.eu/) and the Specialized Working Group on Granulocytes and Constitutional Bone Marrow Failure Syndromes of the European Hematology Association. Whenever evidence was not available, recommendations were based on the expert's panel opinion. Consensus-based recommendations are related to granulocyte colony-stimulating factor indications and schedule of administration, indications for hematopoietic stem cell transplantation, supportive treatments and measures, and new treatments that have been evolving over the recent years. These guidelines, rather than a numerical correction of the absolute neutrophil count, suggest a holistic, patient-centered approach aiming at optimizing the management of chronic neutropenic patients and offering valuable and practical guidance to the hematologists for their daily clinical practice.eng
dc.identifier.doi10.1002/hem3.70113
dc.identifier.eid105003289612
dc.identifier.issn2572-9241
dc.identifier.pmcPMC12001981
dc.identifier.pmid40242664
dc.identifier.urihttp://hdl.handle.net/10400.14/53943
dc.identifier.wos001468549800001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleEuropean guidelines on treatment and supportive measures in chronic neutropenias: a consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence revieweng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.titleHemaSphere
oaire.citation.volume9
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
118141461.pdf
Size:
600.61 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIIS - Contribuições em Revistas Científicas / Contribution to Journals