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EBV and MSI status in gastric cancer: does it matter?

2023-01Journal article Open access
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dc.contributor.authorNascimento, Catarina Neto do
dc.contributor.authorMascarenhas-Lemos, Luís
dc.contributor.authorSilva, João Ricardo
dc.contributor.authorMarques, Diogo Sousa
dc.contributor.authorGouveia, Catarina Ferreira
dc.contributor.authorFaria, Ana
dc.contributor.authorVelho, Sónia
dc.contributor.authorGarrido, Rita
dc.contributor.authorMaio, Rui
dc.contributor.authorCosta, Andreia
dc.contributor.authorPontes, Patrícia
dc.contributor.authorWen, Xiaogang
dc.contributor.authorGullo, Irene
dc.contributor.authorCravo, Marília
dc.contributor.authorCarneiro, Fátima
dc.date.accessioned2023-02-01T09:49:22Z
dc.date.available2023-02-01T09:49:22Z
dc.date.issued2023-01
dc.description.abstractWe investigated the impactof microsatellite instability (MSI) and Epstein–Barr virus (EBV) status in gastric cancer (GC), regarding response to perioperative chemotherapy (POPChT), overall survival (OS), and progression-free survival (PFS). We included 137 cases of operated GC, 51 of which were submitted to POPChT. MSI status was determined by multiplex PCR and EBV status by EBV-encoded RNA in situ hybridization. Thirty-seven (27%) cases presented as MSI-high, and seven (5.1%) were EBV+. Concerning tumor regression after POPChT, no differences were observed between the molecular subtypes, but females were more likely to respond (p = 0.062). No significant differences were found in OS or PFS between different subtypes. In multivariate analysis, age (HR 1.02, IC 95% 1.002–1.056, p = 0.033) and positive lymph nodes (HR 1.82, IC 95% 1.034–3.211, p = 0.038) were the only prognostic factors for OS. However, females with MSI-high tumors treated with POPChT demonstrated a significantly increased OS compared to females with MSS tumors (p = 0.031). In conclusion, we found a high proportion of MSI-high cases. MSI and EBV status did not influence OS or PFS either in patients submitted to POPChT or surgery alone. However, superior survival of females with MSI-high tumors suggests that sex disparities and molecular classification may influence treatment options in GC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/cancers15010074pt_PT
dc.identifier.eid85145987366
dc.identifier.issn2072-6694
dc.identifier.pmcPMC9817503
dc.identifier.pmid36612071
dc.identifier.urihttp://hdl.handle.net/10400.14/40063
dc.identifier.wos000908894900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEpstein–Barr viruspt_PT
dc.subjectFemalespt_PT
dc.subjectGastric cancerpt_PT
dc.subjectGenderpt_PT
dc.subjectMicrosatellite instabilitypt_PT
dc.subjectMolecular subtypept_PT
dc.subjectNeoadjuvant chemotherapypt_PT
dc.subjectPerioperative chemotherapy predictorpt_PT
dc.subjectPrognosispt_PT
dc.titleEBV and MSI status in gastric cancer: does it matter?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume15pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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