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Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life

2015Journal article Restricted access
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dc.contributor.authorKeating, Elisa
dc.contributor.authorCorreia-Branco, Ana
dc.contributor.authorAraújo, João R,
dc.contributor.authorMeireles, Manuela
dc.contributor.authorFernandes, Rita
dc.contributor.authorGuardão, Luísa
dc.contributor.authorGuimarães, João T.
dc.contributor.authorMartel, Fátima
dc.contributor.authorCalhau, Conceição
dc.date.accessioned2015-05-11T17:09:44Z
dc.date.available2015-05-11T17:09:44Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague-Dawley rats (G0) were administered a dose of folic acid (FA) recommended for pregnancy (control, C, 2 mg FA/kg of diet, n=5) or a high dose of FA (HFA, 40 mg FA/kg of diet, n=5). Supplementation began at mating and lasted throughout pregnancy and lactation. Body weight and food and fluid intake were monitored in G0 and their offspring (G1) till G1 were 13 months of age. Metabolic blood profiles were assessed in G1 at 3 and 13 months of age (3M and 13M respectively). Both G0 and G1 HFA females had increased body weight gain when compared with controls, particularly 22 (G0) and 10 (G1) weeks after FA supplementation had been stopped. G1 female offspring of HFA mothers had increased glycemia at 3M, and both female and male G1 offspring of HFA mothers had decreased glucose tolerance at 13M, when compared with matched controls. At 13M, G1 female offspring of HFA mothers had increased insulin and decreased adiponectin levels, and G1 male offspring of HFA mothers had increased levels of leptin, when compared with matched controls. In addition, feeding of fructose to adult offspring revealed that perigestational exposure to HFA renders female progeny more susceptible to developing metabolic unbalance upon such a challenge. The results of this work indicate that perigestational HFA exposure the affects long-term metabolic phenotype of the offspring, predisposing them to an insulin-resistant state.por
dc.description.versioninfo:eu-repo/semantics/submittedVersion
dc.identifier.citationKEATING, Elisa …[et al.] - Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life. Journal of Endocrinology. ISSN 1479-6805. Vol. 224, n.º 3 (2015), p. 245-259por
dc.identifier.doi10.1530/JOE-14-0448
dc.identifier.eid84924787631
dc.identifier.eissn1479-6805
dc.identifier.issn0022-0795
dc.identifier.pmid25663705
dc.identifier.urihttp://hdl.handle.net/10400.14/17550
dc.identifier.wos000349562500010
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBioScientifica
dc.subjectDietary supplementationpor
dc.subjectFetal programingpor
dc.subjectFolic acidpor
dc.subjectMetabolic syndromepor
dc.subjectPregnancypor
dc.titleExcess perigestational folic acid exposure induces metabolic dysfunction in post-natal lifepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage259
oaire.citation.issue3
oaire.citation.startPage245
oaire.citation.titleJournal of Endocrinology
oaire.citation.volume224
person.familyNameKeating
person.familyNameMeireles
person.familyNameGuardao
person.familyNameGuimarães
person.familyNameMartel
person.familyNameCalhau
person.givenNameElisa
person.givenNameManuela
person.givenNameLuisa
person.givenNameJoão Tiago
person.givenNameFátima
person.givenNameConceição
person.identifier517090
person.identifier.ciencia-id2E1C-FAA4-A661
person.identifier.ciencia-idE817-6AD8-E6C3
person.identifier.ciencia-id5C14-37B4-FDCA
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0002-3904-9907
person.identifier.orcid0000-0003-3703-0011
person.identifier.orcid0000-0002-1826-8107
person.identifier.orcid0000-0003-4836-6311
person.identifier.orcid0000-0002-0525-3416
person.identifier.orcid0000-0001-9567-3379
person.identifier.ridT-3079-2017
person.identifier.scopus-author-id35612071300
person.identifier.scopus-author-id7102733078
person.identifier.scopus-author-id7005164101
person.identifier.scopus-author-id6701578877
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscovery5198a1f6-6e2e-4951-ad26-2e93dae6596f

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