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Chitosan as an effective inhibitor of multidrug resistant Acinetobacter baumannii

2017Journal article Restricted access
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dc.contributor.authorCosta, E. M.
dc.contributor.authorSilva, S.
dc.contributor.authorVicente, S.
dc.contributor.authorVeiga, M.
dc.contributor.authorTavaria, F.
dc.contributor.authorPintado, M. M.
dc.date.accessioned2017-11-14T15:06:28Z
dc.date.available2017-11-14T15:06:28Z
dc.date.issued2017
dc.description.abstractOver the last two decades worldwide levels of antibiotic resistance have risen leading to the appearance of multidrug resistant microorganisms. Acinetobacter baumannii is a known skin pathogen which has emerged as a major cause of nosocomial outbreaks due to its capacity to colonize indwelling medical devices and natural antibiotic resistance. With chitosan being an effective antimicrobial agent against antibiotic resistant microorganisms, the aim of this work was to access its potential as an alternative to traditional antimicrobials in the management of A. baumannii growth. What the results showed was that both chitosan MW’s tested were active upon A. baumannii’s planktonic and sessile growth. For planktonic growth MICs and MBCs were obtained at relatively low concentrations (0.5–2 mg/mL) while for sessile growth chitosan proved to be an effective inhibitor of A. baumannii’s adhesion and biofilm formation. Considering these results chitosan shows a high potential for control of A. baumannii infections.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, E. M., Silva, S., Vicente, S., Veiga, M., Tavaria, F., Pintado, M. E. (2017). Chitosan as an effective inhibitor of multidrug resistant Acinetobacter baumannii. Carbohydrate Polymers, 138, 347-351pt_PT
dc.identifier.doi10.1016/j.carbpol.2017.09.055pt_PT
dc.identifier.eid85029610784
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pmid29050604
dc.identifier.urihttp://hdl.handle.net/10400.14/23367
dc.identifier.wos000413038000039
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation17819
dc.relationTextile staining: Toward a greener and functional solution
dc.subjectAcinetobacter baumanniipt_PT
dc.subjectChitosanpt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAntibiofilmpt_PT
dc.subjectClinical isolatept_PT
dc.subjectMultidrug-resistancept_PT
dc.titleChitosan as an effective inhibitor of multidrug resistant Acinetobacter baumanniipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTextile staining: Toward a greener and functional solution
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F103957%2F2014/PT
oaire.citation.endPage351
oaire.citation.startPage347
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume178
oaire.fundingStream5876
person.familyNameCosta
person.familyNameSilva
person.familyNameVeiga
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameMariana
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier1888852
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0002-1815-3270
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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