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Glycerylphytate crosslinker as a potential osteoinductor of chitosan-based systems for guided bone regeneration

2020Journal article Restricted access
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dc.contributor.authorMora-Boza, Ana
dc.contributor.authorGarcía-Fernández, Luis
dc.contributor.authorBarbosa, Filipe A.
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorVázquez-Lasa, Blanca
dc.contributor.authorSan Román, Julio
dc.date.accessioned2020-05-06T15:06:19Z
dc.date.available2020-05-06T15:06:19Z
dc.date.issued2020
dc.description.abstractChitosan-based membranes are promising systems for guided bone regeneration. In this work, we used glycerylphytate as ionic crosslinker and osteinductor compound for the fabrication of chitosan membranes as supports for human mesenchymal stem cells. Three different glycerylphytate-crosslinked membranes were developed by changing the crosslinker concentration, from 2.5–10 wt-%, respect to chitosan. Physico-chemical characterization in terms of composition, morphology, and thermal behavior was further analyzed. Swelling degree, crosslinking density, and crosslinker release showed a glycerylphytate content-dependent behavior. Glycerylphytate suggested to improve osteointegration ability of chitosan surfaces by the formation of apatitelike aggregates after incubation in body simulated fluid. Stem cells cultured on the membranes increased their viability over time, and the incorporation of glycerylphytate improved osteogenic and osteoinductivity potential of chitosan by increasing calcium deposition and alkaline phosphatase (ALP) activity on cultured stem cells.These results demonstrated a potential application of glycerylphytate-crosslinked chitosan systems for promising bone tissue regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMora-Boza, A., García-Fernández, L., Barbosa, F. A., Oliveira, A. L., Vázquez-Lasa, B., & San Román, J. (2020). Glycerylphytate crosslinker as a potential osteoinductor of chitosan-based systems for guided bone regeneration. Carbohydrate Polymers, 241, 116269pt_PT
dc.identifier.doi10.1016/j.carbpol.2020.116269pt_PT
dc.identifier.eid85084108896
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pmid32507162
dc.identifier.urihttp://hdl.handle.net/10400.14/30514
dc.identifier.wos000539100600030
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSFRH/ BPD/116024/2016pt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationNORTE-01-0145-FEDER-000012pt_PT
dc.subjectGlycerylphytatept_PT
dc.subjectChitosan Ionic crosslinkingpt_PT
dc.subjectOsteogenesispt_PT
dc.subjectMesenchymal stem cellspt_PT
dc.subjectGuided bone regenerationpt_PT
dc.titleGlycerylphytate crosslinker as a potential osteoinductor of chitosan-based systems for guided bone regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume241pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMora Boza
person.familyNameGarcía-Fernández
person.givenNameAna
person.givenNameLuis
person.identifier.orcid0000-0002-4366-6860
person.identifier.orcid0000-0002-4179-2556
person.identifier.ridB-8034-2016
person.identifier.ridA-7629-2012
person.identifier.scopus-author-id56993917400
person.identifier.scopus-author-id35262249400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc5284cde-c0cf-4737-902e-6ec8a406d846
relation.isAuthorOfPublicatione6990b39-8d31-41a3-b178-805f7a427a62
relation.isAuthorOfPublication.latestForDiscoveryc5284cde-c0cf-4737-902e-6ec8a406d846
relation.isProjectOfPublication1f76a7db-2520-482f-b56b-7e01ea36dd1f
relation.isProjectOfPublication.latestForDiscovery1f76a7db-2520-482f-b56b-7e01ea36dd1f

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