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Do clear aligners release toxic chemicals? - a systematic review

2025-05-10Review article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFerreira, Mariana
dc.contributor.authorCosta, Hélder
dc.contributor.authorVeiga, Nélio
dc.contributor.authorCorreia, Maria J.
dc.contributor.authorGomes, Ana T. P. C.
dc.contributor.authorLopes, Pedro C.
dc.date.accessioned2025-08-13T15:27:28Z
dc.date.available2025-08-13T15:27:28Z
dc.date.issued2025-05-10
dc.description.abstractClear aligners are a modern orthodontic solution designed to address dental malocclusions discreetly and effectively. In terms of clinical side effects, the most reported issues among aligner users are mild irritation of the oral mucosa, localized inflammation, and hypersensitivity. The use of advanced polymer materials in clear aligners, such as polyurethane and PET-G, has gained widespread acceptance due to their mechanical properties, biocompatibility, and aesthetic appeal. However, concerns persist regarding their potential to release chemical compounds. Our goal is to understand the impact of clear aligner toxicity on the oral cavity of orthodontic patients. An extensive systematic search was conducted in the electronic databases PubMed, Scopus, and Cochrane to identify articles with relevant data. This systematic review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines (PRISMA) to answer a question formulated according to the Population, Intervention, Comparison, and Outcomes. Four hundred and thirteen articles potentially relevant were identified and after applying PRISMA guidelines and inclusion/exclusion criteria, seven articles were included in this review. Our results suggest that clear aligners are generally safe, but concerns remain regarding the chemical leaching of thermoplastic materials, bacterial accumulation due to reduced saliva flow, and mild inflammatory responses. Our review emphasizes that although most materials are biocompatible, some exhibit moderate cytotoxicity, with the potential to impact these patients’ oral health, underscoring the need for continued research and improvements in material composition.eng
dc.identifier.citationFerreira, M., Costa, H., Veiga, N., & Correia, M. J. et al. (2025). Do clear aligners release toxic chemicals? - a systematic review. Journal of Functional Biomaterials, 16(5), Article 173. https://doi.org/10.3390/jfb16050173
dc.identifier.doi10.3390/jfb16050173
dc.identifier.eid105006541814
dc.identifier.issn2079-4983
dc.identifier.other040f9f1e-e510-46f8-9d61-c545739d3e7c
dc.identifier.urihttp://hdl.handle.net/10400.14/54559
dc.identifier.wos001496763800001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdvanced polymer materials
dc.subjectClear aligners
dc.subjectCytotoxicity
dc.subjectOrthodontics
dc.titleDo clear aligners release toxic chemicals? - a systematic revieweng
dc.typereview article
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.titleJournal of Functional Biomaterials
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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