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Inhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis model

2012Journal article Open access
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dc.contributor.authorFernandes, João C.
dc.contributor.authorSereno, José
dc.contributor.authorGarrido, Patricia
dc.contributor.authorParada, Belmiro
dc.contributor.authorCunha, Maria F. X.
dc.contributor.authorReis, Flávio
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorSantos-Silva, Alice
dc.date.accessioned2013-01-28T12:16:13Z
dc.date.available2013-01-28T12:16:13Z
dc.date.issued2012
dc.description.abstractUrinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinogenesis induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. Results indicate that chitooligosaccharides may have a preventive effect on bladder cancer development and a curative effect upon established bladder tumors, dependent on the concentration ingested 500 mg/kg b.w., every three days, showed capacity to inhibit and prevent the proliferation of bladder cancer; however, this was associated with secondary effects such as hypercholesterolemia and hypertriglyceridemia. The use of lower doses (50 and 250 mg/kg b.w.) showed only therapeutic effects. It is further suggested that this antitumor effect might be due to its expected anti-inflammatory action, as well as by mechanisms not directly dependent of COX-2 inhibition, such as cellular proliferation control and improvement in antioxidant profile.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationFERNANDES, João C... [et al.] - Inhibition of Bladder Tumor Growth by Chitooligosaccharides in an Experimental Carcinogenesis Model. Marine Drugs. ISSN 1660-3397. Vol. 10, n.º 12 (2012), p. 2661-2675por
dc.identifier.doi10.3390/md10122661
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.14/9976
dc.identifier.wosWOS:000312607700004
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPI - Multidisciplinary Digital Publishing Institutepor
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectChitosanspor
dc.subjectBladder cancerpor
dc.subjectChemopreventionpor
dc.subjectChitooligosaccharidespor
dc.titleInhibition of bladder tumor growth by chitooligosaccharides in an experimental carcinogenesis modelpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F81968%2F2011/PT
oaire.citation.endPage2675
oaire.citation.startPage2661
oaire.citation.titleMarine Drugs
oaire.citation.volume10
oaire.fundingStreamSFRH
person.familyNameFernandes
person.familyNameSereno
person.familyNameGarrido
person.familyNameParada
person.familyNameReis
person.familyNamePintado
person.familyNameSantos-Silva
person.givenNameJoão
person.givenNameJosé
person.givenNamePatrícia
person.givenNameBelmiro
person.givenNameFlávio
person.givenNameMaria Manuela
person.givenNameAlice
person.identifier2208278
person.identifier456608
person.identifier1368242
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person.identifier.ciencia-id2B15-FEA9-E526
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-id3A11-3945-4DC4
person.identifier.orcid0000-0003-1556-1698
person.identifier.orcid0000-0002-9607-6653
person.identifier.orcid0000-0002-0457-6790
person.identifier.orcid0000-0002-9911-4926
person.identifier.orcid0000-0003-3401-9554
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0002-2565-3169
person.identifier.ridK-3126-2013
person.identifier.ridF-5696-2013
person.identifier.ridK-2326-2013
person.identifier.scopus-author-id35274726800
person.identifier.scopus-author-id35102071200
person.identifier.scopus-author-id56024083800
person.identifier.scopus-author-id7004405551
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id6603836490
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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